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|Title: ||Novel cuminaldehyde self-emulsified nanoemulsion for enhanced antihepatotoxicity in carbon tetrachloride-treated mice|
|Authors: ||Adu-Frimpong, Michael|
Firempong, Caleb Kesse
Mukhtar, Yusif Mohammed
|Issue Date: ||2019|
|Publisher: ||, Journal of Pharmacy and Pharmacology|
|Abstract: ||Objectives Cuminaldehyde self-emulsified nanoemulsion (CuA-SEN) was prepared
and optimised to improve its oral bioavailability and antihepatotoxicity.
Methods Cuminaldehyde self-emulsified nanoemulsion was developed through
the self-nanoemulsification method using Box–Behnken Design (BBD) tool while
appropriate physicochemical indices were evaluated. The optimised CuA-SEN
was characterised via droplet size (DS), morphology, polydispersity index (PDI),
zeta potential (ZP), entrapment efficiency, in-vitro release, and pharmacokinetic
studies while its antihepatotoxicity was evaluated.
Key findings Cuminaldehyde self-emulsified nanoemulsion with acceptable
characteristics (mean DS-48.83 1.06 nm; PDI-0.232 0.140; ZP29.92
1.66 mV; EE-91.51 0.44%; and drug-loading capacity (DL)-
9.77 0.75%) was formulated. In-vitro drug release of CuA-SEN significantly
increased with an oral relative bioavailability of 171.02%. Oral administration of
CuA-SEN to CCl4-induced hepatotoxicity mice markedly increased the levels of
superoxide dismutase, glutathione and catalase in serum. Also, CuA-SEN
reduced the levels of tumour necrosis factor-alpha and interleukin-6 in both
serum and liver tissues while aspartate aminotransferase, alanine aminotransferase
and malonaldehyde levels were significantly decreased.
Conclusions These findings showed that the improved bioavailability of cuminaldehyde
via SEN provided an effective approach for enhancing antioxidation,
anti-inflammation and antihepatotoxicity of the drug.|
|Description: ||An article published by , Journal of Pharmacy and Pharmacology and also available at doi: 10.1111/jphp.13112|
|Appears in Collections:||College of Science|
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