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Title: | Crystal structure and in vitro antimicrobial activity studies of Robustic acid and other alpinumisoflavones isolated from Millettia thonningii |
Authors: | Harrison, Jerry Joe E.K. Ayine-Tora, Moscoh Daniel Appiagyei, Benjamin Mills-Robertson, Felix C. Asomaning, William A. et. al |
Keywords: | antibacterial isoflavone robustic acid Salmonella typhi Staphylococcus aureus |
Issue Date: | 2018 |
Publisher: | Stockholm University Library |
Abstract: | We report a systematic study of the antibacterial
inhibitory potential of isoflavone natural products isolated
from the seeds extracts of Millettia thonningii. In an effort
to gain bond topological information which may have
consequences for the observed bioactivities, the crystal
structure of robustic acid was solved and refined using the
independent atom as well as the invariom model, and the
structures were compared. Robustic acid contains a fused
tricyclic unit with a benzopyran moiety, with a phenylene
ring substitution on the coumarin ring similar to the alpinumisoflavones
isolated from this plant. At a minimum
inhibitory concentration of ~1 mg/mL, alpinumisoflavone
and robustic acid were found to be cytotoxic to Staphylococcus
aureus (ATCC 25923) showing a zone of inhibition
(ZOI) of ~9 mm. On the other hand, at ~2 mg/mL, these
compounds were found to be bacteriostatic to a hospital
isolate of Salmonella typhi with about 7 mm ZOI. Taken
together, these compounds offer potential new avenues
for targeting both Gram positive and negative bacteria
and could be useful as chemical probes for understanding
these pathogens in an effort to overcome drug resistance. |
Description: | An article published by Stockholm University Library and also available at https://doi.org/10.1515/zkri-2018-2052 |
URI: | http://hdl.handle.net/123456789/12882 |
Appears in Collections: | College of Science
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