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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/12918

Title: Antimalarial efficacy and toxicological assessment of extracts of some Ghanaian medicinal plants.
Issue Date: 2019
Publisher: Hindawi
Abstract: Te economic costs associated with morbidity and mortality due to malaria and malaria associated complications in many subSaharan countries and other malaria endemic regions of the world are huge. Reports of emergence of parasite resistance to current malaria drugs have complicated malaria treatment and require the development of new therapeutic agents. Te folkloric use of medicinal plants for the management of malaria is well documented. Tis work evaluated the antiplasmodial activities and toxicity of some medicinal plants used to treat malaria and malaria-like symptoms in Ghana. Plant extracts were obtained by cold maceration in 70% ethanol. Antiplasmodial efcacies were assessed in vitro against 3 strains of Plasmodium falciparum strains (FCM, W2, and CAM06) and in vivo via the 4-day suppressive test in Plasmodium berghei infected mice. Cytotoxicity and acute toxicity were assessed in mammalian cells and mice, respectively. All extracts were active against at least one of the Plasmodium falciparum strains in in vitro evaluations with IC50’s in the range of 4–116 �g/mL, whereas Bidens pilosa extracts, with a chemosuppression rate of 75%, was the most active plant in the in vivo experiments. All plant extracts displayed very weak to no cytotoxicity against the mammalian cell line used and exhibited very good selectivity towards the Plasmodium parasites. Syzygium guineense and Parinari congensis extracts were the most toxic in the acute toxicity tests. Altogether, the results indicate that the medicinal plants do possess impressive antiplasmodial properties and provide scientifc basis for their use in traditional herbal medicine.
Description: An article published by Hindawi and also available at https://doi.org/10.1155/2019/1630405
URI: http://hdl.handle.net/123456789/12918
Appears in Collections:College of Health Sciences

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