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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13047

Title: Seroprevalence, risk factors and impact of Toxoplasma gondii infection on haematological parameters in the Ashanti region of Ghana: a cross-sectional study
Authors: Agordzo, Samuel Kekeli
Badu, Kingsley
Addo, Mathew Glover
Owusu, Christian Kwasi
Mutala, Abdul-Hakim
Tweneboah, Austine
Abbas, Dawood Ackom
Ayisi-Boateng, Nana Kwame
Keywords: Toxoplasma gondii
Haematology
Seroprevalence
IgG
Exposure
Risk Factors
Issue Date: 17-Jun-2020
Publisher: AAS Open Research
Citation: AAS Open Research
Abstract: Background: Toxoplasma gondii is an obligate, intracellular, apicomplexan parasite that causes toxoplasmosis. Although the global prevalence of toxoplasmosis has been estimated to be approximately 30%, there is limited seroprevalence data in Ghana, with a dearth of information on the impact of T. gondii on haematological parameters in exposed persons. Methods: Questionnaires were administered to 300 consenting individuals to obtain demographic information and assessment of their risk of exposure to T. gondii. Using anti- T. gondii IgG/IgM combo test kits, seropositivity to parasite-specific IgG and/or IgM was determined. A haematological analyser was used to measure haematological parameters. Results: There was an overall seroprevalence of 50.3% (n=151), with 49.7% (n=149) of the study participants seropositive for IgG and 1% (n=3) testing positive for IgM. Furthermore, the observed seroprevalence among pregnant women was 56.4% (n=62). With regard to settlement type, a seroprevalence of 55.6% was observed in the rural community, 50.6% in the peri-urban community and 47.1% in the urban community. The study identified cat ownership, contact with cat litter, contact with raw meat [RR (95% CI: 1.76 (1.23-2.53), 1.66 (1.03-2.67), 1.25(1.00-1.57)] and age (p<0.001) as risk factors for infection. Analyses of haematological data revealed significant reduction in the white blood cell, lymphocytes and mean corpuscular volume levels in seropositive males (p=0.0223, 0.0275, and 0.0271) respectively. Only the mean corpuscular volume of seropositive females reduced significantly as compared to the seronegative counterparts (p=0.0035). Conclusions: About half of the study population, including women of reproductive age carried antibodies against T. gondii, raising concerns about the risk of congenital toxoplasmosis and anaemia. We, therefore, recommend that screening for Toxoplasma gondii be included in the routine screening of pregnant women seeking antenatal care and further investigation should be conducted on the haematological implications of infection in humans.
Description: This article is published in AAS Open Researchand is available at https://doi.org/10.12688/aasopenres.13022.2
URI: 10.12688/aasopenres.13022.2
http://hdl.handle.net/123456789/13047
Appears in Collections:College of Science

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