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|Title: ||The Relationship Between Plasma Concentrations of Lutein and Zeaxanthin with Self-Reported and Actual Prevalence of AMD in an Irish Population- Based Sample|
|Authors: ||Moran, Rachel|
O’Halloran, Aisling M.
Akuffo, Kwadwo O.
Kenny, Rose Anne
Nolan, John M.
age-related macular degeneration
|Issue Date: ||27-Nov-2017|
|Publisher: ||Current Eye Research|
|Citation: ||Current Eye Research|
|Abstract: ||Purpose: To investigate plasma lutein (L) and zeaxanthin (Z) concentrations with grading-confirmed and
self-reported prevalence of age-related macular degeneration (AMD).
Material and methods: Data collected from a nationally representative prospective cohort study of
community-dwelling adults aged 50 years and over in the Republic of Ireland. Participants underwent
a computer-assisted personal interview and a center-based health assessment. Plasma concentrations of
L and total Z (Z and meso-zeaxanthin [MZ]) were measured by high performance liquid chromatography,
and retinal photographs were graded using a version of the AMD International Classification and
Grading System. Consumption of supplements containing L and/or Z and/or MZ was recorded as
supplement use. Four groups were identified: Group 1 (n = 24): AMD-afflicted and correctly aware;
Group 2 (n = 264): AMD-afflicted but unaware; Group 3 (n = 41): AMD-free and incorrectly believed that
they were afflicted with the condition; Group 4 (n = 4094): AMD-free and correctly self-reported absence
Results: Of 4,423 participants with plasma concentrations of L and Z and gradable retinal photographs,
288 (6.5%) were afflicted with AMD, and 65 (1.5%) self-reported AMD. Controlling for family history and
age, the relationship between grading-confirmed AMD and plasma L was positive and significant
(p < 0.001). Mean plasma concentrations of L in Group 2 (mean = 0.2162 ± 0.132 μmol) and Group 4
(mean = 0.2040 ± 0.121 μmol/L) were significantly lower than Group 1 (mean = 0.4691 ± 0.0.372 μmol/L)
and Group 3 (mean = 0.3176 ± 0.0.235 μmol/L). Supplement use was reported by 41.7% and 17.1% of
participants in Groups 1 and 3, respectively, but only 2.7% and 1.9% of participants in Groups 2 and 4,
Conclusion: A belief that one suffers from AMD, whether justified or not, is associated with supplement
use and with higher plasma concentrations of L.|
|Description: ||This article is published in CURRENT EYE RESEARCH and is available at https://doi.org/10.1080/02713683.2017.1403633|
|Appears in Collections:||College of Science|
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