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|Title: ||Toxicity and Safety Implications of Herbal Medicines Used in Africa|
|Authors: ||Firempong, Caleb|
Anning, Alexander K.
Dickson, Rita A.
Mensah, Merlin L.K
|Keywords: ||traditional medicine|
|Issue Date: ||Jan-2019|
|Publisher: ||Herbal Medicine|
|Citation: ||Herbal Medicine|
|Abstract: ||The use of herbal medicines has seen a great upsurge globally. In developing countries,
many patronize them largely due to cultural acceptability, availability and cost. In developed
countries, they are used because they are natural and therefore assumed to be safer
than allopathic medicines. In recent times, however, there has been a growing concern about
their safety. This has created a situation of ambivalence in discussions regarding their use.
Some medicinal plants are intrinsically toxic by virtue of their constituents and can cause
adverse reactions if inappropriately used. Other factors such as herb-drug interactions, lack
of adherence to good manufacturing practice (GMP), poor regulatory measures and adulteration
may also lead to adverse events in their use. Many in vivo tests on aqueous extracts
largely support the safety of herbal medicines, whereas most in vitro tests on isolated single
cells mostly with extracts other than aqueous ones show contrary results and thus continue
the debate on herbal medicine safety. It is expected that toxicity studies concerning herbal
medicine should reflect their traditional use to allow for rational discussions regarding their
safety for their beneficial use. While various attempts continue to establish the safety of various
herbal medicines in man, their cautious and responsible use is required.|
|Description: ||This article has been published in Herbal Medicine and available at http://dx.doi.org/10.5772/intechopen.72437|
|Appears in Collections:||College of Science|
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