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|Title: ||Hepatoprotective Potential of Hura crepitans L.: A Review of Ethnomedical, Phytochemical and Pharmacological Studies|
|Authors: ||Larbie, Christopher|
Owojuyigbe, Oluwole S.
Firempong, Caleb K.
Emikpe, Benjamin O.
|Keywords: ||Hura crepitans L|
|Issue Date: ||24-Mar-2020|
|Publisher: ||Journal of Complementary and Alternative Medical Research|
|Citation: ||Journal of Complementary and Alternative Medical Research,9(2): 1-10, 2020;|
|Abstract: ||Herbal medicines are the main source of treatment of diseases in non-urban centres of the
developing world. Secondary metabolites obtained from herbal sources contain bioactive
phytochemicals, many of which have been the origin for the development of novel pharmaceutical
drugs. Hura crepitans L. (Euphorbiaceae) or sandbox tree has been beneficial in many
ethnomedicinal applications as a purgative, emetic, hepatoprotective, anti-inflammatory,
antimicrobial and the treatment of leprosy. Toxicological, phytochemical and bactericidal studieshave also been documented. This paper reviews the potential of the Hura crepitans plant in
protecting the liver against drug-induced toxicity. The paper dwells extensively on the
ethnomedical, phytochemical and pharmacological properties of the plant. In achieving the above,
intensive analyses of books and published peer-reviewed journal articles were carried out using
credible scientific databases. Four main phytochemicals were revealed to be contained in Hura
crepitans stem-bark. Their protective effects were enunciated using animal models. However much
more biochemical studies need to be done to establish the hepatoprotective potentials of the
various parts and various phytochemicals of Hura crepitans with the need for more preclinical and
clinical studies. We, therefore, present in this paper efforts to elucidate and bring to the fore the
therapeutic potentials of Hura crepitans plant.|
|Description: ||This article has been published by Journal of Complementary and Alternative Medical
Research and is also available at DOI: 10.9734/JOCAMR/2020/v9i230136|
|Appears in Collections:||College of Science|
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