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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13101

Title: Hydroethanolic Extracts of Ficus pumila Linn. Is Protective against Gentamicin-Induced Kidney Damage in Rats
Authors: Larbie, Christopher
Siaw, Portia A
Zon, Solomon
Appiah-Kubi, Kwame
Keywords: Nephrotoxicity
Ficus pumila Linn. creatinine
urea
electrolytes
Issue Date: 15-Jun-2018
Publisher: Journal of Advances in Medical and Pharmaceutical Sciences
Citation: Journal of Advances in Medical and Pharmaceutical Sciences,17(2): 1-8, 2018,
Abstract: Ficus pumila Linn. has been reported to be rich in phenols, hepatoprotective and antiproliferative on leukemic cancer cells. The aim of this study was to evaluate the nephroprotective effect of hydroethanolic leaves extracts of F. pumila on gentamicin-induced kidney damage in rats. Twentyseven female Wistar albino rats were divided into 9 groups (n=3). Group 1 being normal; group 2 was the gentamicin (GM) induced only (80 mg/kg b/w ip for 5 days); groups 3, 4, & 5 rats were treated with gentamicin (80mg/kg b/w ip for 5 days) and F. pumila extract at 100, 250, and 500 mg/kg b/w orally respectively; groups 6, 7 & 8 rats received the extract only (100, 250, and 500 mg/kg b/w orally) respectively and group 9 being gentamicin and silymarin (100 mg/kg b/w orally) for 21 days. Blood samples were taken 24 hrs after the experimented period and biochemical and haematological parameters were analyzed. GM nephrotoxicity was characterized by significantlyincreased levels of serum creatinine, urea, sodium, potassium and WBC, while reduced RBC, HGB, MCH and MCV levels compared with normal group. Rats treated with gentamicin and the extract showed a significant reduction in the levels of these markers. The results suggest that hydroethanolic extract of Ficus pumila leaves protect against gentamicin-induced nephrotoxicity in female Wistar albino rats
Description: This article has been published by Journal of Advances in Medical and Pharmaceutical Sciences and is also available at DOI: 10.9734/JAMPS/2018/41291
URI: 10.9734/JAMPS/2018/41291
http://hdl.handle.net/123456789/13101
Appears in Collections:College of Science

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