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|Title: ||Interleukin–6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B) rs2383207 are associated with ischemic stroke in indigenous West African Men|
|Authors: ||Akinyemi, Rufus|
Arnett, Donna K.
Tiwari, Hemant K.
Sarfo, Fred Stephen
Irvin, Marguerite Ryan
Perry, Rodney T.
Cyclin dependent kinase inhibitor
|Issue Date: ||2017|
|Publisher: ||Journal of the Neurological Sciences|
|Citation: ||Journal of the Neurological Sciences, 379 (2015) 229–235|
|Abstract: ||Background: Inherited genetic variations offer a possible explanation for the observed peculiarities of stroke in
sub - Saharan African populations. Interleukin–6 polymorphisms have been previously associated with ischemic
stroke in some non-African populations.
Aim: Herein we investigated, for the first time, the association of genetic polymorphisms of IL-6, CDKN2ACDKN2B
and other genes with ischemic stroke among indigenous West African participants in the Stroke Investigative
Research and Education Network (SIREN) Study.
Methods: Twenty-three previously identified single nucleotide polymorphisms (SNPs) in 14 genes of relevance to
the neurobiology of ischemic stroke were investigated. Logistic regression models adjusting for known cardiovascular
disease risk factorswere constructed to assess the associations of the 23 SNPs in rigorously phenotyped
cases (N=429) of ischemic stroke (Men=198;Women=231) and stroke– free (N=483) controls (Men=
236; Women = 247).
Results: Interleukin-6 (IL6) rs1800796 (C minor allele; frequency:West Africans=8.6%) was significantly associated
with ischemic stroke in men (OR = 2.006, 95% CI = [1.065, 3.777], p = 0.031) with hypertension in the
model but not in women. In addition, rs2383207 in CDKN2A/CDKN2B (minor allele A with frequency:West Africans=
1.7%) was also associated with ischemic stroke inmen (OR=2.550, 95% CI=[1.027, 6.331], p=0.044)
with primary covariates in the model, but not inwomen. Polymorphisms in other genes did not showsignificant
association with ischemic stroke.|
|Description: ||An article published in Journal of the Neurological Sciences, 379 (2015) 229–235|
|Appears in Collections:||College of Health Sciences|
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