|
KNUSTSpace >
Research Articles >
College of Health Sciences >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/13355
|
Title: | Burden and Predictors of Poststroke Cognitive Impairment in a Sample of Ghanaian Stroke Survivors |
Authors: | Sarfo, Fred Stephen Akassi, John Adamu, Sheila Obese, Vida Ovbiagele, Bruce |
Keywords: | Vascular dementia Risk factors Quality of life Ghana |
Issue Date: | Nov-2017 |
Publisher: | Journal of Stroke and Cerebrovascular Diseases |
Citation: | Journal of Stroke and Cerebrovascular Diseases, Vol. 26, No. 11 (November), 2017: pp 2553–2562 |
Abstract: | Background and Objective: There are limited data on vascular cognitive impairment
(VCI) from low- and middle-income countries where the stroke burden is
burgeoning. The aim of this study was to characterize the burden, determinants,
and effects of VCI on health-related quality of life in sub-Saharan Africa (SSA).
Methods: From January 2015 to February 2016, we collected information on 147
consecutive stroke survivors (>45 years) seen at a tertiary hospital in Ghana and
49 demographically matched stroke-free controls. Data collected included demographics,
clinical factors, health-related quality of life, and presence of depression.
Cognitive status was evaluated using a standard Vascular Neuropsychological Battery
that assessed memory, executive function and mental speed, language, and
visuospatial–visuoconstructive functioning. Expert VCI guideline and Diagnostic
and Statistical Manual of Mental Disorders—Fourth Edition criteria were used to
classify stroke patients into no VCI, VCI but no dementia, and vascular dementia
(VD). Results: The mean age ± standard deviation of the stroke survivors was
59.9 ± 13.7 years, of which 47.6% were women. Among the cohort, 77 out of 147
(52.3%) had no VCI, 50 of the 147 (34.0%) had VCI without dementia, and 20 of
the 147 (13.6%) had VD. Three factors remained significantly associated with VCI:
increasing age for each successive 10-year rise (odds ratio [OR] 1.44, 95% confidence
interval [CI]: 1.03-2.02), lack of formal education (OR 5.26, 95% CI: 1.01-
27.52), and worse functional disability on the modified Rankin scale (OR 2.46,
95% CI: 1.61-3.75). Patients with VD had the poorest health-related quality of life.
Conclusions: Half of the Ghanaian stroke survivors encountered in this crosssectional
study had evidence of cognitive dysfunction. Future studies in SSA will
need to identify strategies to address this immense burden. Key Words: —risk factors—quality of life—Ghana. |
Description: | An article published in Journal of Stroke and Cerebrovascular Diseases, Vol. 26, No. 11 (November), 2017: pp 2553–2562 |
URI: | http://hdl.handle.net/123456789/13355 |
Appears in Collections: | College of Health Sciences
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|