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|Title: ||APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke|
|Authors: ||Akinyemi, Rufus|
Tiwari, H. K.
Arnett, D. K.
Irvin, M. R.
Sarfo, Fred Stephen
Perry, R. T. ..et.al.
|Keywords: ||African Ancestry|
Small vessel disease
|Issue Date: ||11-Sep-2017|
|Publisher: ||Acta Neurol Scand|
|Citation: ||Akinyemi R, Tiwari HK, Arnett DK, et al. APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke. Acta Neurol Scand. 2018;137:133–141; https://doi.org/10.1111/ane.12847|
|Abstract: ||Objective: Worldwide, the highest frequencies of APOL1-associated
are found in indigenous West Africans among whom small vessel disease (SVD) ischemic
stroke is the most common stroke phenotype. The objective of this study was
to investigate the association and effect sizes of 23 selected SNPs in 14 genes of relevance,
including the APOL1 G1 variants, with the occurrence of SVD ischemic stroke
among indigenous West African participants in the Stroke Investigative Research and
Education Network (SIREN) Study.
Materials and Methods: Cases were consecutively recruited consenting adults (aged
18 years or older) with neuroimaging—confirmed first clinical stroke. Stroke-free
were ascertained using a locally validated version of the Questionnaire for
Status (QVSFS). Logistic regression models adjusting for known
vascular risk factors were fitted to assess the associations of the 23 SNPs in rigorously
phenotyped cases (N = 154) of SVD ischemic stroke and stroke-free
(N = 483)
Results: Apolipoprotein L1 (APOL1) rs73885319 (OR = 1.52; CI: 1.09-2.13,
= .013), rs2383207 in CDKN2A/CDKN2B (OR = 3.08; CI: 1.15-8.26,
value = .026) and rs2107595 (OR = 1.70; CI: 1.12-2.60,
= .014) and
rs28688791 (OR = 1.52; CI: 1.03-2.26,
= .036) in HDAC9 gene were associated
with SVD stroke at 0.05 significance level. Polymorphisms in other genes did not
show significant associations.
Conclusion: This is the first report of a specific association of APOL1 with a stroke
subtype. Further research is needed to confirm these initial findings and deepen understanding
of the genetics of stroke in people of African ancestry with possible implications
for other ancestries as all humans originated from Africa.|
|Description: ||An article published by Akinyemi R, Tiwari HK, Arnett DK, et al. APOL1, CDKN2A/CDKN2B, and HDAC9 polymorphisms and small vessel ischemic stroke. Acta Neurol Scand. 2018;137:133–141; https://doi.org/10.1111/ane.12847|
|Appears in Collections:||College of Health Sciences|
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