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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13380

Title: Clinical and Bacteriological Efficacy of Rifampin-Streptomycin Combination for Two Weeks followed by Rifampin and Clarithromycin for Six Weeks for Treatment of Mycobacterium ulcerans Disease
Authors: Phillips, Richard Odame
Sarfo, Fred Stephen
Abass, Mohammed K.
Abotsi, Justice
Wilson, Tuah
Forson, Mark
Amoako, Yaw A.
Thompson, William
Asiedu, Kingsley
Wansbrough-Jones, Mark
Issue Date: Feb-2014
Publisher: Antimicrobial Agents and Chemotherapy
Citation: Antimicrobial Agents and Chemotherapy, Vol.58, No. 2, p. 1161–1166, February,2014
Abstract: Buruli ulcer, an ulcerating skin disease caused by Mycobacterium ulcerans infection, is common in tropical areas of western Africa. We determined the clinical and microbiological responses to administration of rifampin and streptomycin for 2 weeks followed by administration of rifampin and clarithromycin for 6 weeks in 43 patients with small laboratory-confirmed Buruli lesions and monitored for recurrence-free healing. Bacterial load in tissue samples before and after treatment for 6 and 12 weeks was monitored by semiquantitative culture. The success rate was 93%, and there was no recurrence after a 12-month follow-up. Eight percent had a positive culture 4 weeks after antibiotic treatment, but their lesions went on to heal. The findings indicate that rifampin and clarithromycin can replace rifampin and streptomycin for the continuation phase after rifampin and streptomycin administration for 2 weeks without any apparent loss of efficacy.
Description: An article published by Antimicrobial Agents and Chemotherapy, Vol.58, No. 2, p. 1161–1166, February,2014
URI: http://hdl.handle.net/123456789/13380
Appears in Collections:College of Health Sciences

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