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Title: | Characteristics of hypertension among people living with HIV in Ghana: Impact of new hypertension guideline |
Authors: | Sarfo, Fred Stephen Nichols, Michelle Singh, Arti Hardy, Yasmine Norman, Betty Mensah, Gideon Tagge, Ralle Jenkins, Carolyn Ovbiagele, Bruce |
Issue Date: | 2019 |
Publisher: | J Clin Hypertens. |
Citation: | J Clin Hypertens. 2019;21:838–850. |
Abstract: | Data on the burden of hypertension among people living with HIV (PLWH) in Africa
are limited, especially after new expert consensus hypertension guidelines were
published in 2017. The authors sought to assess the prevalence and factors associated
with hypertension among PLWH. This is a cross‐sectional study involving
PLWH on combination antiretroviral therapy (cART) (n = 250) compared with sexmatched
cART‐naïve PLWH (n = 201) in Ghana. Hypertension was defined as blood
pressure ≥ 140/90 mm Hg or use of antihypertensive drugs. The authors also assessed
the prevalence and predictors associated with hypertension using the recent
guideline recommended cutoff BP ≥ 130/80 mm Hg. Multivariate logistic regression
models were fitted to identify factors associated with hypertension among PLWH.
The mean age of PLWH on cART was 45.7 ± 8.6 years, and 42.9 ± 8.8 years among
PLWH cART‐naive with 81% of study participants being women. The prevalence of
hypertension among PLWH on cART and PLWH cART‐naïve was 36.9% and 23.4%,
P = 0.002 at BP ≥ 140/90 mm Hg and 57.2% and 42.3%, respectively, P = 0.0009, at
BP ≥ 130/80 mm Hg. Factors associated with hypertension at BP ≥ 140/90 mm Hg
in the PLWH group with adjusted odds ratio (95% CI) were increasing age, 2.08
(1.60‐2.71) per 10 years, and body mass index, 1.53 (1.24‐1.88) per 5 kg/m2 rise. At
BP ≥ 130/80 mm Hg, cART exposure, aOR of 1.77 (95% CI: 1.20‐2.63), family history
of hypertension, aOR of 1.43 (1.12‐1.83), and hypertriglyceridemia, aOR of 0.54
(0.31‐0.93), were associated with hypertension. Among PLWH, cART exposure was
associated with higher prevalence of hypertension per the new guideline definition, a
finding which warrants further investigation and possible mitigation. |
Description: | An article published in J Clin Hypertens. 2019;21:838–850. |
URI: | http://hdl.handle.net/123456789/13407 |
Appears in Collections: | College of Health Sciences
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