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Title: | Clinical and epidemiological characterisation of Burkitt’s lymphoma: an eight-year case study at Komfo Anokye Teaching Hospital, Ghana |
Authors: | Owusu, L. Yeboah, F. A Osei-Akoto, Alex Rettig, T. Arthur, F. K. N. |
Keywords: | Burkitt’s lymphoma Neoplasms |
Issue Date: | 2016 |
Publisher: | Taylor & Francis |
Citation: | British Journal of Biomedical Science |
Abstract: | Endemic Burkitt’s lymphoma (BL) is a juvenile malignant
neoplasm of B-lymphocyte origin, markedly affected by
climate, vegetation and geographical location. This real
country-based, cross-sectional, retrospective study reviews
all out-patient clinical records of patients histologically
and/or clinically diagnosed with BL from January, 2000 to
December, 2007 at the Komfo Anokye Teaching Hospital,
Ghana, a country within the malaria and lymphoma belts
of the world. The aim of the study is to clinically and
epidemiologically characterise all cases of BL over an eightyear
period to ascertain the most common form of BL
demographically prevalent. A mean age of 6.9±2.7 (range:
1–16) was observed. Males generally dominated in
incidence (M:F=1.43:1, P< 0.001) and significantly with
facial presentation (P<0.05). Females weakly dominated in
abdominal tumour presentation (P>0.05). The age range
4–8 years was the high risk range (P< 0.001) for both sexes.
Males were affected early in life (4–7 years) compared to
their female counterparts (6–11 years). Of the 551 cases
reviewed, 48.3%, 32.7%, 15.8% and 3.3% involved the face,
abdomen, combined facial and abdominal and either facial
or abdominal with central nervous system (CNS)
involvement (usually paraplegia), respectively. An intriguing
observation was evident between facial and combined facial
and abdominal cases which exhibited reversed trends in
incidence. Three regions within the forest zone showed
significantly higher (P< 0.001) incidences compared to the
seven cohorts from the coastal and savannah agro-ecological
zones of Ghana. No region was explicitly associated with any
particular clinical presentation. The study has shown that
although BL can present with demographic patterns in
prevalence within a given geographical location, no clinical
characterisation is associated with such patterns. |
Description: | This article is published in Taylor and Francis and also available at http://dx.doi.org/10.1080/09674845.2010.11730283 |
URI: | 10.1080/09674845.2010.11730283 http://hdl.handle.net/123456789/13416 |
Appears in Collections: | College of Agric and Natural Resources
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