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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13417

Title: Screening LRRK2 gene mutations in patients with Parkinson’s disease in Ghana
Authors: Cilia, Roberto
Sironi, Francesca
Akpalu, Albert
Cham, Momodou
Sarfo, Fred Stephen
Brambilla, Tiziana
Bonetti, Alba
Amboni, Marianna
Issue Date: Jan-2011
Publisher: Journal of Neurology
Citation: Journal of Neurology;vol. 258,no.1, January, 2011; DOI 10.1007/s00415-011-6210-y
Abstract: The leucine-rich repeat kinase 2 (LRRK2) gene is associated with autosomal dominant Parkinson disease (PD) [1]. Its most common mutation G2019S may account for 3–6% of familial and 1–2% of sporadic PD cases. This mutation’s frequency may range from\0.1% in Asia to 43% in North Africa, even in apparently sporadic cases [2, 3] because of its low penetrance [4]. To date, this is the first screening of LRRK2 mutations in Ghana and only the third in a sub- Saharan African country [5, 6].
Description: An article punlished in Journal of Neurology;vol. 258,no.1, January, 2011; DOI 10.1007/s00415-011-6210-y
URI: http://hdl.handle.net/123456789/13417
Appears in Collections:College of Health Sciences

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