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|Title: ||Microchimerism in Ghanaian children recipients of whole blood transfusion for severe anaemia|
|Authors: ||Assennato, Sonny Michael|
Lambert, Nathalie C.
|Issue Date: ||2018|
|Publisher: ||Vox Sanguinis|
|Abstract: ||Background and objectives Transfusion-acquired microchimerism (TA-Mc) has
been reported in major trauma but not in young children despite relative immunodeficiency
who, in sub-Saharan Africa, often suffer severe anaemia related to
haemoglobinopathies or primary malaria infections. We examined the hypothesis
that such massive red cell destructions might provide conditions favourable to
TA-Mc, particularly when exposed to massive amounts of parasite antigens.
Materials and Methods Twenty-seven female children <5 years transfused with
male whole blood for severe anaemia (13 with acute malaria and 14 with other
causes) were retrospectively identified, and a blood sample was collected
>6 months post-transfusion. Four whole blood samples from paediatric females
transfused with blood from female donors and five secondary school female students
never pregnant, never transfused were used as negative controls.
Results Nineteen patients (70%) carried male Mc with four (15%) having high
levels of Mc (>100 genome equivalent of male cells/million of host cells) compared
to three controls (37 5%). There was no difference in frequency or quantity
of male Mc between paediatric patients with severe malaria and paediatric
patients with other causes of severe anaemia. TA-Mc was not correlated with
patient age, duration of whole blood storage or lymphocyte load transfused. After
a median of 7 months post-transfusion, acute malaria did not increase the frequency
of TA-Mc. One negative control appeared to carry low-level male cells.
Conclusion Transfusion-acquired microchimerism appears frequent in young children
transfused with whole blood for severe anaemia.
Key words: anaemia, malaria, microchimerism, sub-Saharan Africa, transfusion|
|Description: ||This article is published in Vox Sanguinis and also available at DOI: 10.1111/vox.12734|
|URI: ||DOI: 10.1111/vox.12734|
|Appears in Collections:||College of Agric and Natural Resources|
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