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Title: | Some conventional and non-conventional hematological and biochemical markers for characterizing some acute and chronic presentations of sickle cell patients |
Authors: | Nsiah, Kwabena Dzogbefia, Victoria Pearl Ansong, Daniel Osei-Akoto, Alex Ocloo, Dela |
Keywords: | Sickle cell hemoglobinopathy hemolytic markers conventional nonconventional |
Issue Date: | 2013 |
Publisher: | Journall off Investtiigattiionall Biochemiisttry |
Abstract: | Background: Some acute and chronic presentations of sickle cell disease (SCD) are
splenomegaly, acute chest syndrome (ACS), priapism and leg ulceration. Hematological and
biochemical parameters are used for diagnosis and prognosis.
Method: In this cross-sectional study, carried out over a 12-month period, involving 291
patients, some conventional hematological and biochemical parameters, and two nonconventional
determinations, aspartate aminotranferase: alanine aminotransferase (AST:ALT)
ratio and urine color, were used to characterize the patients with some selected clinical
presentations.
Results: For these subjects studied (n = 21), the mean values of hemoglobin (Hb), red blood
cells (RBC), white blood cells, (WBC), reticulocytes, platelets and fetal hemoglobin (HbF)
were 6.6 g/dl, 2.28×1012/L; 16.3 ×109/L, 27.1%, 310.1×109/L and 1.84%, respectively. The
mean AST:ALT ratio was 2.058 and the urine color, 2.381. Thesevalues were compared to 5
non-anemic counterparts, who had the following mean values of the parameters; Hb = 11.9
g/dl; RBC = 4.13×1012/L WBC = 7.2×109/L; reticulocytes = 5.2%; platelets = 282.4×109/L;
HbF = 1.48%. A Mann-Whitney non parametric two-tailed test showed several of the
differences between the patients with complications and the non-anemic, were statistically
significant (p < 0.05). The subjects with the complications were moderately anemic, having
elevated levels of lactate dehydrogenase, total bilirubin, indirect bilirubin and AST:ALT ratio.
Conclusion: The four clinical presentations were characterized by anemia, accompanied by
high levels of conventional markers, like reticulocytes, lactate dehydrogenase (LDH) and
bilirubin, together with an elevated AST:ALT ratio, a non-conventional marker. |
Description: | This article is published in Journall off Investtiigattiionall
Biochemiisttry and also available at DOI: 10.5455/jib.20121217043354 |
URI: | 10.5455/jib.20121217043354 http://hdl.handle.net/123456789/13469 |
Appears in Collections: | College of Agric and Natural Resources
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