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|Title: ||Evaluation of the Adequacy of the 2010 Revised World Health Organization Recommended Dosages of the First-line Antituberculosis Drugs for Children|
|Authors: ||Yang, Hongmei|
Gillani, Fizza S.
|Keywords: ||First-line antituberculosis drugs|
WHO revised dosages
|Issue Date: ||2018|
|Publisher: ||HHS Public Access|
|Abstract: ||Background—The World Health Organization recommended increased dosages of the first-line antituberculosis (anti-TB) drugs for children in 2010. We examined the frequency of and factors associated with low plasma maximum concentration (Cmax) of each drug in children treated with the revised dosages.
Methods—Children on anti-TB therapy for at least 4 weeks underwent pharmacokinetic testing. Plasma Cmax below the lower limit of proposed reference range was considered low. Bivariate and multivariate analyses were used to examine the factors associated with low Cmax of each drug.|
|Description: ||This article is published in HHS Public Access and also available at doi:10.1097/INF.0000000000001687.|
|Appears in Collections:||College of Agric and Natural Resources|
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