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|Title: ||Aim: This study assesses the effects of HAART on complete blood count parameters among HIV infected participants. Study Design: Case control study. Place and Methods: This study was conducted in Tamale, Ghana from August, 2016 to December, 2017. Methodology: A total of 300 HIV infected participants with ages ranging from 19–79 years, administered with HAART for at least 6 months were recruited. Pre-HAART administratio|
|Authors: ||Bani, Simon Bannison|
Danquah, Kwabena O.
Owiredu, William K. B. A.
Sakyi, Samuel Asamoah
Dapare, Peter Paul M.
Gandau, Barnabas B. N.
|Keywords: ||Highly active antiretroviral therapy|
|Issue Date: ||2020|
|Publisher: ||International STD Research & Reviews|
|Citation: ||International STD Research & Reviews 9(2): 8-16, 2020; Article no.ISRR.59518 ISSN: 2347-5196, NLM ID: 101666147|
|Abstract: ||Methodology: A total of 300 HIV infected participants with ages ranging from 19 to 79 years who
have been administered with HAART for at least 6 months were recruited. Pre-HAART
administration (baseline) demographic and clinical information, with initial liver and renal function
test results were retrieved from the medical records of the participants present at the ART center.
Post HAART administration blood sample (5 mLs) was taken from each participant into a gel
separated vacutainer tube, allowed to clot and spun at 3000 rpm for 3 minutes to produce serum.
The product (serum) was used for liver and renal function test analysis using a fully automated
chemistry analyser (Vital Scientific Selectra Flexor XL).
Results: Of the study population, 72% were administered with AZT/3TC/EFV, 13% with
AZT/3TC/NVP, 6.7% with TDF/3TC/LPV/r and TDF/3TC/NVP, 1% with AZT/3TC/EFV while 0.7%
were administered with TDF/FTC/EFV. The following parameters were significantly increased post
HAART administration; ALT (25.53 ± 16.90 to 30.87 ± 19.28 U/L), ALP (163.7 ± 141.0 to 215.2 ±
143.4 U/L), GGT (37.27 ± 25.21 to 53.19 ± 41.71 U/L), Total protein (73.97 ± 17.08 to 82.31 ±
11.62 g/L), Albumin (38.02 ± 9.331 to 41.01 ± 7.471 g/L), Globulin 38.02 ± 15.71 to 42.79 ± 25.20
(g/L). There were however significant reductions in Total bilirubin (12.13 ± 10.85 to 9.434 ± 4.560
μmol/L), Direct bilirubin (6.616 ± 5.770 to 4.184 ± 2.806 μmol/L), (Creatinine 73.19 ± 36.13 to 63.14
± 27.14 μmol/L) and Urea (3.515 ± 2.552 to 3.011±1.274 mmol/L).
Conclusion: HAART improves renal function, induces elevation in liver enzymes, stimulates the
production of plasma proteins and reduces serum bilirubin concentration.|
|Description: ||An article published in International STD Research & Reviews 9(2): 8-16, 2020; Article no.ISRR.59518 ISSN: 2347-5196, NLM ID: 101666147|
|Appears in Collections:||College of Health Sciences|
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