KNUSTSpace >
Research Articles >
College of Health Sciences >
Please use this identifier to cite or link to this item:
http://hdl.handle.net/123456789/13545
|
Title: | Quality and safety evaluation of a Ghanaian polyherbal product EAF-2011 for the management of superficial mycoses |
Authors: | R.A, Dickson Mensah, M.L.K K.P, Thomford Annan, K Mills-Robertson, F.C Appiah, AA Quarshie, O Antwi, Sampson Kaminta, S Edoh, D |
Keywords: | Analytical markers chronic toxicity polyherbal formulation safety standardisation superficial mycoses |
Issue Date: | 2013 |
Publisher: | International Journal of Medicine and Biomedical Research |
Abstract: | The widespread use of herbal medicines in recent years
means that issues concerning their quality, safety and efficacy need to be
answered. In the current study, the polyherbal formulation EAF-2011 used in
the Centre for Scientific Research into Plant Medicine, Mampong-
Akwapemfor the management of superficial mycoses was evaluated for its
quality and safety. Aim: The study sought to evaluate the quality and safety
of the product in the management of superficial mycoses. Method: The
method of standardisation using the basic phytochemical screening and the
thin layer chromatography procedures was used. The stability was also
assessed using the thin layer chromatography, an antimicrobial assay and
the physicochemical properties of the product. A safety evaluation of the
product was also performed using a skin sensitisation and chronic toxicity
test in male Sprague-Dawley rats. Results: The product demonstrated
stability during the study period of one year as results obtained from the thin
layer chromatography, physicochemical and biological assay did not indicate
any significant change in characteristics. Alkaloids, phenols, flavonoids,
sterols and triterpenes were detected in the product. Three spots obtained
by the thin layer chromatography were shown to be ideal for use as
analytical markers for the product. Haematological, biochemical, urine and
histopathological data at the end of the study did not indicate any adverse
effect from the herbal treatments. Conclusion: The study thus showed the
ointment to be safe for the management of superficial mycoses. |
Description: | This article is published in International Journal of Medicine and Biomedical Research |
URI: | http://hdl.handle.net/123456789/13545 |
Appears in Collections: | College of Health Sciences
|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
|