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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13593

Title: Developing a Modified Low-Density Lipoprotein (M-LDL-C) Friedewald’s Equation as a Substitute for Direct LDL-C Measure in a Ghanaian Population: A Comparative Study
Authors: Ephraim, Richard K. D.
Acheampong, Emmanuel
Swaray, Swithin M.
Anto, Enoch Odame
Agbodzakey, Hope
Adoba, Prince
Afranie, Bright Oppong
Batu, Emmanuella Nsenbah
Adu, Patrick
Fondjo, Linda Ahenkorah
Sakyi, Samuel Asamoah
Amoah, Beatrice
Issue Date: 2018
Publisher: Journal of Lipids
Citation: Journal of Lipids, Volume 2018, Article ID 7078409, 9 pages, https://doi.org/10.1155/2018/7078409
Abstract: Despite the availability of several homogenous LDL-C assays, calculated Friedewald’s LDL-C equation remains the widely used formula in clinical practice. Several novel formulas developed in different populations have been reported to outperform the Friedewald formula. This study validated the existingLDL-C formulas and derived amodifiedLDL-C formula specific to aGhanaian population. In this comparative study, we recruited 1518 participants, derived a new modified Friedewald’s LDL-C (M-LDL-C) equation, evaluated LDL-C by Friedewald’s formula (F-LDL-C), Martin’s formula (N-LDL-C), Anandaraja’s formula (A-LDL-C), and compared them to direct measurement of LDL-C (D-LDL-C). The mean D-LDL-C (2.47±0.71 mmol/L) was significantly lower compared to F-LDL-C (2.76±1.05 mmol/L), N-LDL-C (2.74±1.04 mmol/L), A-LDL-C (2.99±1.02 mmol/L), and M-LDL-C (2.97±1.08 mmol/L) p < 0.001.There was a significantly positive correlation between D-LDL-C and A-LDL-C (r=0.658, p<0.0001), N-LDL-C (r=0.693, p<0.0001), and M-LDL-C (r=0.693, p<0.0001). M-LDL-c yielded a better diagnostic performance [(area under the curve (AUC)=0.81; sensitivity (SE) (60%) and specificity (SP) (88%)] followed by N-LDL-C [(AUC=0.81; SE (63%) and SP (85%)], F-LDL-C [(AUC=0.80; SE (63%) and SP (84%)], and A-LDL-C (AUC=0.77; SE (68%) and SP (78%)] using D-LDL-C as gold standard. Bland–Altman plots showed a definite agreement between means and differences of D-LDL-C and the calculated formulas with 95% of values lying within ±0.50 SD limits.The modified LDL-C (M-LDL-C) formula derived by this study yielded a better diagnostic accuracy compared to A-LDL-C and F-LDL-C equations and thus could serve as a substitute for D-LDL-C and F-LDL-C equations in the Ghanaian population.
Description: An article published in Journal of Lipids, Volume 2018, Article ID 7078409, 9 pages, https://doi.org/10.1155/2018/7078409
URI: http://hdl.handle.net/123456789/13593
Appears in Collections:College of Health Sciences

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