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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/13595

Title: Evaluating Vitamin D Status in Pre- and Postmenopausal Type 2 Diabetics and Its Association with Glucose Homeostasis
Authors: Fondjo, Linda Ahenkorah
Sakyi, Samuel Asamoah
Owiredu, William K. B. A.
Laing, Edwin Ferguson
Owiredu, Eddie-Williams
Awusi, Ebenezer Kwesi
Ephraim, Richard K. D.
Kantanka, Osei Sarfo
Issue Date: 2018
Publisher: BioMed Research International
Citation: BioMed Research International Volume 2018, Article ID 9369282, 12 pages, https://doi.org/10.1155/2018/9369282
Abstract: Background. Type 2 Diabetes Mellitus (T2DM) and menopause are associated with vitamin D status. Oestrogen decline during menopausal stages promotes hypovitaminosis D. However, the interplay between vitamin D, menopause, lifestyle, and T2DM cannot be overlooked. This study assessed vitamin D status among pre- and postmenopausal T2DM women and determined its association with glycemic control and influence of lifestyle habits on hypovitaminosis D. Methods.This cross-sectional study was conducted at the Komfo Anokye Teaching Hospital, Kumasi, Ghana. Structured questionnaires were administered to 192 T2DM women; blood samples were collected for estimation of 25(OH) D and insulin using ELISA. Fasting blood glucose (FBG), lipid profile, glycated haemoglobin (HbA1c), and calcium were measured. Statistical analyses were performed using Graphpad Prism 6. Results.The prevalence of vitamin D inadequacy was 92.2%. Hypovitaminosis D was more prevalent among the postmenopausal T2DM women (63.8% versus 58.2%). Hypovitaminosis D significantly associated with insulin [𝑅2 = 0.01760, 𝑝 = 0.0008], HbA1c [𝑅2 = 0.3709, 𝑝 =< 0.0001], and FBG [𝑅2 = 0.3465, 𝑝 = 0.0001] in only the postmenopausal women. Conclusion. Vitamin D deficiency is prevalent in pre- and postmenopausal T2DM but higher among postmenopausal women. Adequate vitamin D levels in both groups were associated with improved glucose control while hypovitaminosis D in the postmenopausal women was related to poorer glucose control. Vitamin D screening should be incorporated into management plan for T2DM to serve as an early tool for prevention of vitamin D deficiency.
Description: An article published in BioMed Research International Volume 2018, Article ID 9369282, 12 pages, https://doi.org/10.1155/2018/9369282
URI: http://hdl.handle.net/123456789/13595
Appears in Collections:College of Health Sciences

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