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|Title: ||Adverse pregnancy outcomes and imbalance in angiogenic growth mediators and oxidative stress biomarkers is associated with advanced maternal age births: A prospective cohort study in Ghana|
|Authors: ||Anto, Enoch Odame|
Owiredu, William K. B. A.
Sakyi, Samuel Asamoah
Turpin, Cornelius Archer
Ephraim, Richard K. D.
Fondjo, Linda Ahenkorah
|Issue Date: ||2018|
|Publisher: ||Plos One|
|Citation: ||Odame Anto E, Owiredu WKBA, Sakyi SA, Turpin CA, Ephraim RKD, Fondjo LA, et al. (2018) Adverse pregnancy outcomes and imbalance in angiogenic growth mediators and oxidative stress biomarkers is associated with advanced maternal age births: A prospective cohort study in Ghana. PLoS ONE 13(7): e0200581. https://doi.org/ 10.1371/journal.pone.0200581|
Advanced maternal age (AMA) has been associated with negative pregnancy outcomes.
Oxidative stress (OS) and defective placental dysfunction are contributing factors. This
study determined the association between AMA and adverse pregnancy outcomes, OS biomarkers
and angiogenic growth mediators (AGMs) in normal pregnancies.
This prospective cohort study conducted at the Obstetrics and Gynaecology (O&G) Department
of the Komfo Anokye Teaching Hospital (KATH) finally included 175 normal pregnant
women comprising, 58 AMA (35±45 years), 55 (30±34 years) and 62 optimal childbearing
age (20±29 years). Venous blood samples were collected at 28±32 weeks for soluble fmslike
tyrosine kinase-1 (sFlt-1), placental growth factor (PIGF), 8-epiprostaglandinF2-α (8-
epi-PGF2α) and total antioxidant capacity (TAC) assays.
Pregnancies of AMA had a significantly higher levels of sFlt-1, 8-epi-PGF2α and 8-epi-
PGF2α: PIGF ratio but a reduced level of PIGF, TAC and PIGF: sFlt-1 ratio compared to
20±29 years (p<0.0001). A significant negative correlation between AMA and PIGF (r =
-0.294; p = 0.038); TAC (r = -0.215; p = 0.001) and PIGF: sFlt-1 ratio (r = -0.457; p<0.0001)
and a positive correlation with sFlt-1 (r = 0.269; p = 0.017), 8-epiPGF2α (r = 0.277; p = 0.029) and 8-epi-PGF2: PIGF ratio (r = 0.461; p<0.0001) levels were observed. The
adjusted odds ratio (aOR), and 95% confidence interval, and p value for the significant independent
adverse outcomes associated with AMA were emergency caesarean section [21.7
(5.9±121.3), p<00001], elective caesarean section [2.7(0.9±5.8), p = 0.0105], stillbirth [12.6
(1.4±82.1), p<0.0001], post-partum haemorrhage [4.3(1.1±18.5), p = 0.0094], preterm delivery
[8.2(3.5±28.4), p<0.0001], low birth weight babies [9.7(2.8±29.3), p<0.0001], birth
asphyxia [3.8(1.6±12.7), p = 0.0054], Apgar score 7 after 5 min for babies [10.1(4.7±
23.2), p<0.0001], placental abruption [3.5(1.3±8.4), p = 0.0117] and intrauterine growth
restriction (IUGR) [4.6(2.3±12.9), p = 0.0001].
AMA pregnancies correlate with adverse pregnancy outcomes and imbalance in OS biomarkers
and AGMs. It is incumbent on health care givers to provide effective antenatal care
among AMA mothers as early identification of these imbalance and treatment can prevent
adverse pregnancy outcomes.|
|Description: ||An article published by Odame Anto E, Owiredu WKBA, Sakyi SA,
Turpin CA, Ephraim RKD, Fondjo LA, et al. (2018)
Adverse pregnancy outcomes and imbalance in
angiogenic growth mediators and oxidative stress
biomarkers is associated with advanced maternal
age births: A prospective cohort study in Ghana.
PLoS ONE 13(7): e0200581. https://doi.org/
|Appears in Collections:||College of Health Sciences|
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