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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14511

Title: Antinociceptive properties of the hydroethanol stem bark extract of Burkea Africana (hook.) (fabaceae)
Authors: Jibira, Yakubu
Boakye-Gyas, Eric
Keywords: Antinociceptive
Hydroethanol
Burkea Africana
Issue Date: 28-Jul-2021
Abstract: Pain is a major symptom of many clinical disorders and its relief has long been a dominant concern for individuals across the globe. There is therefore an unmet need to search for new agents with improved efficacy for more effective management of pain. The stem bark of the savanna tree Burkea africana (Hook) (Family: Leguminosae) is used in the Ghanaian traditional medicine for the treatment and management of various pain-related diseases. The present study investigated the acute toxicity and the analgesic effects of an ethanolic extract of the stem bark of Burkea africana (BAE) in rodent models. Phyto-constituents including saponins, tannins, reducing sugars, phytosterols, triterpenoids, flavonoids and alkaloids were detected in the preliminary qualitative test of the extract. Toxicity study was conducted in mice. None of the animals died in the BAE treated groups and also no observable changes in the gross anatomical appearance of the mice. The LD50 was estimated to be above 5000 mg kg-1. The extract showed significant anti-nociceptive activity in the various nociceptive paradigms: acetic acid-induced writhing assay, carrageenan-induced nociception, acidic saline induced muscle pain, formalin-induced nociception and vincristine-induced peripheral neuropathic pain model in rodents. BAE (50, 500 and 1000 mg kg-1 p.o.) showed an antiallodynic effect similar to pregabalin in the vincristine-induced neuropathy by increasing paw withdrawal latency and paw withdrawal threshold. Also, the extract decreased the levels of lipid peroxidation products (Malondialdehyde) and myeloperoxidase and induced a significant increase in endogenous antioxidants enzymes (Superoxide Dismutase, Catalase and reduced Glutathione) levels in the vincristine-treated rats. The anti-nociceptive effects of BAE in the formalin test was completely reduced by naloxone, granisetron and glibenclamide. However, yohimbine, nifedipine, reserpine and theophylline did not affect the anti-nociceptive effects of the extract. In conclusion, this study provides evidence to support the use of the stem bark of Burkea africana (Hook) in the management of pain in the Ghanaian traditional medicine practice.
Description: A thesis submitted to the Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences in partial fulfillment of the requirements for the Degree of Master of Philosophy Kwame Nkrumah University of Science and Technology, Kumasi, Ghana .June, 2019
URI: http://hdl.handle.net/123456789/14511
Appears in Collections:College of Health Sciences

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