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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14702

Title: Antioxidant Properties and Anti-Inflammatory Activities of Cucumeropsis Edulis (Seeds)
Authors: Badu, Mercy
Agbemade, Blessed
Boateng, Ransford
Amponsah, Isaac
Boamah, Vivian
Keywords: Medicinal properties
Oxidative stress
Radical scavenging activity
Issue Date: Sep-2021
Publisher: Research Square
Citation: Research Square
Abstract: This study sought to explore the medicinal properties of extracts obtained from C. edulis seeds. The seeds were obtained from farms in the Upper East Region of Ghana, dried and milled into coarse powder. Petroleum ether, ethyl acetate and methanol were used to extract the bioactive compounds present in the seeds by the cold maceration method. Antioxidant properties of the extracts were evaluated using the Phosphomolybdenum and DPPH free radical scavenging assays. The Folin-Ciocalteu assay was used to estimate the total phenol content and carrageenan-induced paw oedema model in chicks employed for the anti-inflammatory effects. The results showed that methanol extract had the highest antioxidant and anti-inflammatory activities while the petroleum ether extract showed the least activity. The antiinflammatory activity of the methanol extract (31.3% oedema inhibition at 300 mg/kg body weight) was however lower than diclofenac (54.04% oedema inhibition at 100 mg/kg body weight), the reference drug. Compounds such as tannins, alkaloids, and carotenoids detected during phytochemical screening may be responsible for the activities observed
Description: This article is published in Research Square and also available at DOI: https://doi.org/10.21203/rs.3.rs-823782/v1
URI: 10.21203/rs.3.rs-823782/v1
Appears in Collections:College of Science

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