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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/14770

Title: Gut microbiota alterations in response to sleep length among African-origin adults
Authors: Fei, Na
Choo-Kang, Candice
Reutraku, Sirimon
Crowley, Stephanie J.
Bedu-Addo, Kweku
Plange-Rhule, Jacob
Forrester, Terrence E.
Lambert, Estelle V.
Bovet, Pascal
Riesen, Walter
Korte, Wolfgang
Luke, Amy
Layden, Brian T.
Gilber, Jack A.
Dugas, Lara R.
Issue Date: Sep-2018
Publisher: PLOS ONE
Citation: PLOS ONE
Abstract: Sleep disorders are increasingly being characterized in modern society as contributing to a host of serious medical problems, including obesity and metabolic syndrome. Changes to the microbial community in the human gut have been reportedly associated with many of these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on the gut microbiota in a large cohort of 655 participants of African descent, aged 25–45, from Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was self-reported via a questionnaire. Participants were classified into 3 sleep groups: short (<7hrs), normal (7-<9hrs), and long (�9hrs). Forty-seven percent of US participants were classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively correlated with sleep length (p<0.05). Furthermore, sleep length significantly contributed to the inter-individual beta diversity dissimilarity in gut microbial composition (p<0.01). Participants with both short and long-sleep durations exhibited significantly higher abundances of several taxonomic features, compared to normal sleep duration participants. The predicted relative proportion of two genes involved in the butyrate synthesis via lysine pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships revealed by network analysis showed unique interactions among the short, normal and long duration sleepers. These results suggest that sleep length in humans may alter gut microbiota by driving population shifts of the whole microbiota and also specific changes in Exact Sequence Variants abundance, which may have implications for chronic inflammation
Description: This article is published in Plose One and is also available at https://doi.org/10.1371/journal. pone.0255323
URI: 10.1371/journal. pone.0255323
Appears in Collections:College of Health Sciences

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