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|Title: ||Gut microbiota alterations in response to sleep length among African-origin adults|
|Authors: ||Fei, Na|
Crowley, Stephanie J.
Forrester, Terrence E.
Lambert, Estelle V.
Layden, Brian T.
Gilber, Jack A.
Dugas, Lara R.
|Issue Date: ||Sep-2018|
|Publisher: ||PLOS ONE|
|Citation: ||PLOS ONE|
|Abstract: ||Sleep disorders are increasingly being characterized in modern society as contributing to a
host of serious medical problems, including obesity and metabolic syndrome. Changes to
the microbial community in the human gut have been reportedly associated with many of
these cardiometabolic outcomes. In this study, we investigated the impact of sleep length on
the gut microbiota in a large cohort of 655 participants of African descent, aged 25–45, from
Ghana, South Africa (SA), Jamaica, and the United States (US). The sleep duration was
self-reported via a questionnaire. Participants were classified into 3 sleep groups: short
(<7hrs), normal (7-<9hrs), and long (�9hrs). Forty-seven percent of US participants were
classified as short sleepers and 88% of SA participants as long sleepers. Gut microbial composition
analysis (16S rRNA gene sequencing) revealed that bacterial alpha diversity negatively
correlated with sleep length (p<0.05). Furthermore, sleep length significantly
contributed to the inter-individual beta diversity dissimilarity in gut microbial composition
(p<0.01). Participants with both short and long-sleep durations exhibited significantly higher
abundances of several taxonomic features, compared to normal sleep duration participants.
The predicted relative proportion of two genes involved in the butyrate synthesis via lysine
pathway were enriched in short sleep duration participants. Finally, co-occurrence relationships
revealed by network analysis showed unique interactions among the short, normal
and long duration sleepers. These results suggest that sleep length in humans may alter gut
microbiota by driving population shifts of the whole microbiota and also specific changes in
Exact Sequence Variants abundance, which may have implications for chronic inflammation|
|Description: ||This article is published in Plose One and is also available at https://doi.org/10.1371/journal.
|URI: ||10.1371/journal. pone.0255323|
|Appears in Collections:||College of Health Sciences|
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