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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/15100

Title: Inadvertent non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in dual HIV-1/2 and HIV-2 seropositive West Africans: a retrospective study
Authors: Phillips, Richard Odame
Sarfo, Fred S.
Chadwick, David R.
Bibby, David F.
Schwab, Uli
Appiah, Lambert T.
Clark, Duncan A.
Collini, Paul
Green, ngrid
Dittmar, Matthias T.
Keywords: viral load
Issue Date: 23-Jun-2009
Publisher: Journal of Antimicrobial Chemotherapy
Citation: Journal of Antimicrobial Chemotherapy, 2009
Abstract: Sir, HIV-2 or dual HIV-1/2 infection makes up between 4% and 24% of all HIV infections in West Africa, and dual infection 12% of all infections in Ghana.1 HIV-2 infection progresses to AIDS more slowly than HIV-1; however, dual infection appears to progress at a rate similar to that of HIV-1.2 Antiretroviral therapy (ART) has been widely available in Ghana since 2003, with good initial results.3 Non-nucleoside reverse transcriptase inhibitor (NNRTI)-based ART is first-line therapy. In many centres HIV testing has not routinely been type-specific, so patients infected with HIV-2 have started ART including NNRTIs that are ineffective against HIV-2.
Description: This article is published at Journal of Antimicrobial Chemotherapy, and also available at doi:10.1093/jac/dkp216
URI: doi:10.1093/jac/dkp216
Appears in Collections:College of Health Sciences

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