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|Title: ||Inadvertent non-nucleoside reverse transcriptase inhibitor (NNRTI)-based antiretroviral therapy in dual HIV-1/2 and HIV-2 seropositive West Africans: a retrospective study|
|Authors: ||Phillips, Richard Odame|
Sarfo, Fred S.
Chadwick, David R.
Bibby, David F.
Appiah, Lambert T.
Clark, Duncan A.
Dittmar, Matthias T.
|Keywords: ||viral load|
|Issue Date: ||23-Jun-2009|
|Publisher: ||Journal of Antimicrobial Chemotherapy|
|Citation: ||Journal of Antimicrobial Chemotherapy, 2009|
HIV-2 or dual HIV-1/2 infection makes up between 4% and
24% of all HIV infections in West Africa, and dual infection
12% of all infections in Ghana.1 HIV-2 infection progresses to
AIDS more slowly than HIV-1; however, dual infection appears
to progress at a rate similar to that of HIV-1.2 Antiretroviral
therapy (ART) has been widely available in Ghana since 2003,
with good initial results.3 Non-nucleoside reverse transcriptase
inhibitor (NNRTI)-based ART is first-line therapy. In many
centres HIV testing has not routinely been type-specific, so
patients infected with HIV-2 have started ART including
NNRTIs that are ineffective against HIV-2.|
|Description: ||This article is published at Journal of Antimicrobial Chemotherapy, and also available at doi:10.1093/jac/dkp216|
|Appears in Collections:||College of Health Sciences|
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