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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/15240

Title: Two-hit in vitro T-Cell Stimulation Detection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana
Authors: Phillips, Richard Odame
Lundtoft, Christian
Adankwah, Ernest
Güler, Alptekin
Franken, Kees L. M. C.
Ottenhoff, Tom H. M.
Mayatepek, Ertan
Owusu-Dabo, Ellis
Nausch, Norman
Jacobsen, Marc
Keywords: CFP10
LTBI,
tuberculosis,
IGRA,
Mycobacterium tuberculosis latency antigens,
ESAT6,
Issue Date: 1-Apr-2019
Publisher: Frontiers in Immunology
Citation: Frontiers in Immunology, 2019
Abstract: Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis (Mtb). The pathogen is transmitted via aerosols from tuberculosis patients with cavernous disease to close contacts (HCs), who have a high risk of becoming Mtb infected. A minor subset of Mtb infected HCs will develop active tuberculosis whereas the majority will control the pathogen by immune surveillance and remain latently Mtb infected (LTBI) (1). IFN-γ producing CD4+Thelper cells are central for protection of LTBI against progression to active disease. Thelper cells induce a delayed type hypersensitivity reaction against mycobacterial antigens (i.e., Mtb purified protein derivative; PPD) and this recall immune response forms the basis of the tuberculin skin test (TST) for detection of previous Mtb infection. The TST test has been used for more than a century to diagnose Mtb infection. In several regions where tuberculosis is endemic the TST is still applied but replacement by more specific immunological in vitro tests (i.e., IFN-γ release assays, IGRAs) is ongoing (2).
Description: This article is published at Frontiers in Immunology, and also available at doi: 10.3389/fimmu.2019.01518
URI: doi: 10.3389/fimmu.2019.01518
http://hdl.handle.net/123456789/15240
Appears in Collections:College of Health Sciences

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