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|Title: ||Two-hit in vitro T-Cell Stimulation Detection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana|
|Authors: ||Phillips, Richard Odame|
Franken, Kees L. M. C.
Ottenhoff, Tom H. M.
Mycobacterium tuberculosis latency antigens,
|Issue Date: ||1-Apr-2019|
|Publisher: ||Frontiers in Immunology|
|Citation: ||Frontiers in Immunology, 2019|
|Abstract: ||Tuberculosis is a chronic infectious disease caused by
Mycobacterium tuberculosis (Mtb). The pathogen is transmitted
via aerosols from tuberculosis patients with cavernous disease
to close contacts (HCs), who have a high risk of becoming Mtb
infected. A minor subset of Mtb infected HCs will develop active
tuberculosis whereas the majority will control the pathogen by
immune surveillance and remain latently Mtb infected (LTBI)
(1). IFN-γ producing CD4+Thelper cells are central for protection
of LTBI against progression to active disease. Thelper cells induce
a delayed type hypersensitivity reaction against mycobacterial
antigens (i.e., Mtb purified protein derivative; PPD) and this
recall immune response forms the basis of the tuberculin skin
test (TST) for detection of previous Mtb infection. The TST test
has been used for more than a century to diagnose Mtb infection.
In several regions where tuberculosis is endemic the TST is still
applied but replacement by more specific immunological in vitro
tests (i.e., IFN-γ release assays, IGRAs) is ongoing (2).|
|Description: ||This article is published at Frontiers in Immunology, and also available at doi: 10.3389/fimmu.2019.01518|
|URI: ||doi: 10.3389/fimmu.2019.01518|
|Appears in Collections:||College of Health Sciences|
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