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Title: | Characterization of Salmonella enterica from invasive bloodstream infections and water sources in rural Ghana |
Authors: | Dekker, Denise Krumkamp, Ralf Eibach, Daniel Sarpong, Nimako Boahen, Kennedy Gyau Frimpong, Michael Fechtner, Elina Poppert, Sven Hagen, Ralf Matthias Schwarz, Norbert Georg Adu-Sarkodie, Yaw Owusu-Dabo, Ellis Im, Justin Marks, Florian Frickmann, Hagen May, Jürgen |
Keywords: | invasive non-typhoidal Salmonella water sources transmission reservoir |
Issue Date: | Jan-2018 |
Publisher: | BMC Infectious Diseases |
Citation: | BMC Infectious Diseases |
Abstract: | Background: Non-typhoidal Salmonella (NTS) cause the majority of bloodstream infections in Ghana, however the
mode of transmission and source of invasive NTS in Africa are poorly understood. This study compares NTS from
water sources and invasive bloodstream infections in rural Ghana.
Methods: Blood from hospitalised, febrile children and samples from drinking water sources were analysed for
Salmonella spp. Strains were serotyped to trace possible epidemiological links between human and water-derived
isolates.. Antibiotic susceptibility testing was performed,
Results: In 2720 blood culture samples, 165 (6%) NTS were isolated. S. Typhimurium (70%) was the most common
serovar followed by S. Enteritidis (8%) and S. Dublin (8%). Multidrug resistance (MDR) was found in 95 (58%) NTS
isolates, including five S. Enteritidis. One S. Typhimurium showed reduced fluroquinolone susceptibility. In 511 water
samples, 19 (4%) tested positive for S. enterica with two isolates being resistant to ampicillin and one isolate being
resistant to cotrimoxazole. Serovars from water samples were not encountered in any of the clinical specimens.
Conclusion: Water analyses demonstrated that common drinking water sources were contaminated with S. enterica
posing a potential risk for transmission. However, a link between S. enterica from water sources and patients could
not be established, questioning the ability of water-derived serovars to cause invasive bloodstream infections |
Description: | This article is published by BMC Infectious Diseases and is also available at 10.1186/s12879-018-2957-4 |
URI: | 10.1186/s12879-018-2957-4 http://hdl.handle.net/123456789/15353 |
Appears in Collections: | College of Health Sciences
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