Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis
No Thumbnail Available
Date
2023-11-30
Journal Title
Journal ISSN
Volume Title
Publisher
Scientific African, Elsevier
Abstract
Allergic rhinitis (AR) is a growing global health concern. Despite being non-fatal, it has a detrimental effect on people’s quality of life and poses a significant economic burden. In this study, we
aimed to evaluate the anti-allergic effects of aurantio-obtusin against ovalbumin-induced murine
model of allergic rhinitis. Aurantio-obtusin was administered to rats orally after sensitization to
ovalbumin. Results of the study suggested that aurantio-obtusin causes a significant reduction in
nose rubs and sneeze as compared to the vehicle-treated disease control group. The aurantioobtusin treated group showed a dose-dependent significant reduction in serum TNF-α, IL-4,
and IL-6 levels as well as histamine levels in the nasal mucosa. Additionally, it decreased
neutrophil and eosinophil numbers in blood of AR rats’. In the nasal tissues of the vehicle-treated
rats that were subjected to an OVA challenge, the histology of the nasal mucosa of AR rats
revealed aberrant histological changes. A variety of histological abnormalities, including vascular
congestion in the nasal mucosa, substantial inflammatory cell infiltration, and obvious alveolar
wall oedema were present. In the rats treated with aurantio-obtusin, these characteristics were
reversed. Collectively, the findings suggests that aurantio-obtusin could be used to enhance
current AR treatment approaches.
Description
Keywords
Citation
Mavis Sersah Nyarko, Cynthia Amaning Danquah, Aaron Opoku Antwi, Aurantio-obtusin alleviates allergic responses in ovalbumin-induced rhinitis, Scientific African, Volume 23, 2024, e02004,