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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/15704

Title: Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project
Authors: Akinyemi, Rufus O.
Akinwande, Kazeem
Diala, Samuel
Adeleye, Osi
Ajose, Abiodun
Issa, Kehinde
Owusu, Dorcas
Boamah, Isaac
Yahaya, Isah Suleiman
Jimoh, Abdulraheem Olayemi
Imoh, Lucius
Fakunle, Gregory
Akpalu, Albert
Sarfo, Fred Stephen
Wahab, Kolawole
Sanya, Emmanuel
Owolabi, Lukman
Obiako, Reginald
Osaigbovo, Godwin
Komolafe, Morenikeji
Fawale, Michael
Adebayo, Philip
Olowoyo, Paul
Obiabo, Yahaya
Keywords: biobanking
stroke
neurological disorders
Low and Middle Income Countries (LMIC)
Africa
genomics
trans-omics
Issue Date: May-2018
Publisher: Biopreservation and Biobanking 16(3)
Citation: Biopreservation and Biobanking 16(3)
Abstract: Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational, multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from 16 sites in Ghana and Nigeria. SIREN aims to explore and unravel the genetic and environmental factors that interact to produce the peculiar phenotypic and clinical characteristics of stroke as seen in people of African ancestry and facilitate the development of new diagnostics, therapeutics, and preventative strategies. The aim of this article is to describe our experience with the development of the procedure for collection, processing, storage, and shipment of biological samples (blood, serum, plasma, buffy coat, red cell concentrates, and DNA) and brain imaging across coordinating and participating sites within the SIREN Project. The SIREN network was initiated in 2014 with support and funding from the H3Africa Initiative. The SIREN Biobank currently has 3015 brain images, 92,950 blood fractions (serum, plasma, red cell concentrates, and buffy coat) accrued from 8450 recruited subjects, and quantified and aliquoted good-quality DNA extracts from 6150 study subjects.
Description: This article is published by Biopreservation and Biobanking and is also available at DOI: 10.1089/bio.2017.0113
URI: 10.1089/bio.2017.0113
http://hdl.handle.net/123456789/15704
Appears in Collections:College of Health Sciences

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