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Title: | Biobanking in a Challenging African Environment: Unique Experience from the SIREN Project |
Authors: | Akinyemi, Rufus O. Akinwande, Kazeem Diala, Samuel Adeleye, Osi Ajose, Abiodun Issa, Kehinde Owusu, Dorcas Boamah, Isaac Yahaya, Isah Suleiman Jimoh, Abdulraheem Olayemi Imoh, Lucius Fakunle, Gregory Akpalu, Albert Sarfo, Fred Stephen Wahab, Kolawole Sanya, Emmanuel Owolabi, Lukman Obiako, Reginald Osaigbovo, Godwin Komolafe, Morenikeji Fawale, Michael Adebayo, Philip Olowoyo, Paul Obiabo, Yahaya |
Keywords: | biobanking stroke neurological disorders Low and Middle Income Countries (LMIC) Africa genomics trans-omics |
Issue Date: | May-2018 |
Publisher: | Biopreservation and Biobanking 16(3) |
Citation: | Biopreservation and Biobanking 16(3) |
Abstract: | Africa was previously insufficiently represented in the emerging discipline of biobanking despite commendable
early efforts. However, with the Human, Heredity, and Health in Africa (H3Africa) initiative, biorepository
science has been bolstered, regional biobanks are springing up, and awareness about biobanks is growing on the
continent. The Stroke Investigative Research and Educational Network (SIREN) project is a transnational,
multicenter, hospital and community-based study involving over 3000 cases and 3000 controls recruited from
16 sites in Ghana and Nigeria. SIREN aims to explore and unravel the genetic and environmental factors that
interact to produce the peculiar phenotypic and clinical characteristics of stroke as seen in people of African
ancestry and facilitate the development of new diagnostics, therapeutics, and preventative strategies. The aim of
this article is to describe our experience with the development of the procedure for collection, processing,
storage, and shipment of biological samples (blood, serum, plasma, buffy coat, red cell concentrates, and DNA)
and brain imaging across coordinating and participating sites within the SIREN Project. The SIREN network
was initiated in 2014 with support and funding from the H3Africa Initiative. The SIREN Biobank currently has
3015 brain images, 92,950 blood fractions (serum, plasma, red cell concentrates, and buffy coat) accrued from
8450 recruited subjects, and quantified and aliquoted good-quality DNA extracts from 6150 study subjects. |
Description: | This article is published by Biopreservation and Biobanking and is also available at DOI: 10.1089/bio.2017.0113 |
URI: | 10.1089/bio.2017.0113 http://hdl.handle.net/123456789/15704 |
Appears in Collections: | College of Health Sciences
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