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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/15743

Title: Lack of Association of CD55 Receptor Genetic Variants and Severe Malaria in Ghanaian Children
Authors: Agbenyega, Edward Tsiri
Ehmen, Christa
Thye, Thorsten
Schuldt, Kathrin
Sievertsen, Juergen
Evans, Jennifer
May, Juergen
Ansong, Daniel
Muntau, Birgit
Ruge, Gerd
Timmann, Christian
Horstmann, Rolf D.
Keywords: high-resolution screen
genetic association study
Issue Date: 2017
Publisher: G3,
Citation: G3, 2017
Abstract: In a recent report, the cellular receptor CD55 was identified as a molecule essential for the invasion of human erythrocytes by Plasmodium falciparum, the causal agent of themost severe formof malaria.As this invasion process represents a critical step during infection with the parasite, it was hypothesized that genetic variants in the gene could affect severe malaria (SM) susceptibility. We performed high-resolution variant discovery of rare and common genetic variants in the human CD55 gene. Association testing of these variants in over 1700 SMcases and unaffected control individuals from the malaria-endemic Ashanti Region in Ghana, West Africa, were performed on the basis of single variants, combined rare variant analyses, and reconstructed haplotypes. A total of 26 genetic variants were detected in coding and regulatory regions of CD55. Five variants were previously unknown. None of the single variants, rare variants, or haplotypes showed evidence for association with SM or P. falciparum density. Here, we present the first comprehensive analysis of variation in the CD55 gene in the context of SM and show that genetic variants present in a Ghanaian study group appear not to influence susceptibility to the disease.
Description: This article is published at G3, and also available at doi: 10.1534/g3.116.036475
URI: doi: 10.1534/g3.116.036475
Appears in Collections:College of Health Sciences

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