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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1728

Title: Bioequivalence studies of locally manufactured analgesic (Paracod) tablet
Authors: Opuni, Frimpong-Manso Kwabena
Issue Date: 10-Nov-2005
Series/Report no.: 3948;
Abstract: A reverse phase high performance liquid chromatography (HPLC) method was developed for the simultaneous determination of free codeine and paracetamol in urine. A separation was obtained with the mobile phase composition of Methanol-2.5% Glacial acetic acid (15:85, v/v) under isocratic conditions. The separation was achieved with a detector wavelength of 245nm using acetanilide as the internal standard. The proposed method was found to be linear and reproducible. The bioequivalence of a locally manufactured analgesic tablet (PARACOD) and a reference analgesic tablet (CO-CODAMOL) was studied. The drug products met all the pharmacopoeia standards of identity, strength and purity. The relative bioavailability of paracetamol (test drug) and codeine (test drug) were respectively 94.31% and 99.46%. The drug products were bioequivalent.
Description: A thesis submitted to the Department of Pharmaceutical Chemistry in partial fulfillment of the requirement for the degree of Master of Science (Pharmaceutical analysis and quality control), 2005
URI: http://hdl.handle.net/123456789/1728
Appears in Collections:College of Health Sciences

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