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|Title: ||Prevalence of Arterial Cardiovasclar Risk Factors among Hive Patients on Highly Active Antiretroviral Therapy: A Study in Kumasi South Hospital|
|Authors: ||Fianko, Klutse|
|Issue Date: ||14-Jul-2011|
|Abstract: ||This study estimated prevalence of arterial cardiovascular disease risks and type II diabetes among HIV persons on highly active antiretroviral therapy (HAART) at the Kumasi South Hospital. Risk prevalence was measured in 305 HIV positive persons of which 165 (HAART experienced group) have been on HAART for over six (6) months. Biochemical, haematological and anthropometrical variables were measured in all the 305 participants. 23.8% and 11.8% complained of facial and limbs lipoatrophy respectively. 32.2%, 17.1%, 28.7% and 13.4% complained of lipohypertrophy of the neck, breast, abdomen and buttocks respectively. Majority of the HAART experienced participants (41%) used Stavudine, lamivudine and Nevirapine combinations therapy. The prevalence of type II diabetes and IFG among the HAART experienced group were 6.7% and 4.3% respectively. The risk of developing type II diabetes was five (5) times higher than the HAART naïve group: X2(P), 7.3(0.0068). 15.2% and 23.8% HAART experienced group developed systolic and diastolic hypertension after six (6) months on therapy respectively. 7.1% of the systolic hypertension and 11.6% of the diastolic hypertension were using d4T/3TC/NVP respectively. The risk of developing systolic and diastolic hypertension was five (5) times (p<0.05) among the HAART experienced group. The prevalence of hyperlipidaemia among the HAART experienced group was 3.7% (p<0.0001). LDLC and low HDLC were high among the HAART experienced group (p<0.05) and the risk of developing hyperlipidaemia was four (4) times higher than the HAART naïve group. Truncal obesity based on WHR was prevalent among the HAART experienced population, 49.4% were classified as high risk and the risk of developing truncal obesity was three (3) times compared to the HAART naïve group. Type II diabetes showed no significant prevalence in terms of BMI, WHR and WC. However IFG which can be an indication for insulin resistance was associated with BMI, WHR and WC. The HAART experienced participants have increased WHR, WC, blood pressure, glucose, and cholesterol levels. The study revealed a high prevalence of multiple risk factors for arterial cardiovascular disease. Factors such as life style changes and nutrition other than body fat redistribution alone may be contributing to the dyslipidaemia consequently the risk of arterial cardiovascular disease.|
|Description: ||This Thesis Has Been Submitted In Partial Fulfillment Of The Requirements For The Award Of Master of Science Degree In Clinical Biochemistry At The Department Of Molecular Medicine, School Of Medical Sciences, College Of Health Sciences, Kwame Nkrumah University Of Science And Technology Kumasi, Ghana.
|Appears in Collections:||College of Health Sciences|
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