“The effect of hormonal contraceptives on some blood parameters of Ghanaian women "

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1990-03-29
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The blood profile as well as the blood pressure and weight of hundred and nine healthy women whose age ranged between 21 and 49 years were determined. These values were used as control. The blood profile1 blood pressures and weight of fifty three women aged between 25 and 49 years who have been receiving Depoprovera injections for varying lengths of time ranging between 3 months and 17 years were determined. Significant increases in the mean concentrations of serum Glucose, Alkaline Phosphatase, Aspartate aminotransferase, total bilirubin, Albumen, Systolic and Diastolic blood pressures and weight were obtained. The blood profile, blood pressure and weight of seven women aged between 23 and 50 years who have been receiving Neogynon for varying periods of time ranging from one month to 13 years 5 months were determined. Comparison of these values with the controls showed significant increases in the mean concentration of Plasma Glucose, Total Bilirubin, and blood pressure. The blood profile, blood pressure and weight of 13 women aged between 24 and 39 years who have been receiving Eugynon for varying periods of time ranging from one month to 6 years 3 months were determined. This low dose combined contraceptive did not cause significant changes in any of the parameters determined. The blood profile and blood pressure of 5 women aged between 24 and 40 years who have been receiving Nordette low dose combined contraceptive for varying lengths of time ranging from one month to 1 year 7 months were determined. This preparation caused significant increases in the activity of Aspartate aminotransferase and mean concentration of Albumin. These changes could not be correlated with the dose of ethinyl oestradiol and levonorgestrel in this preparation. Generally the contraceptive acceptors were relatively old and multiparous women of mean age and parity 30.65 years and 4.4 live births respectively.
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A thesis submitted to the Board of Postgraduate Studies, Kwame Nkrumah University of Science and Technology, Kumasi, in partial fulfilment of the requirement for the award of the Degree of Master of Philosophy in Chemical Pathology, 1990
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