The bioactive constituents of “chlorophora excelsa” a Ghanaian timber species

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Date
1994-09-04
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Abstract
Thin-layer chromatography of ethanol extract (E1) of the heartwood of Chlorophora Excelsa revealed three (3) components. Fractionation of the ethanol extract was carried out by hydrolysis followed by batch separation with separators funnel. Fractions were monitored by their bioactivity/ microbial activity and one fraction E11 showed the highest activity when tested against brine shrimp Pure E11, was extracted and was found to be phenolic.Acetate derivative (D11) of the phenolic extract (E11) was prepared and was identified by spectra and chemical methods as chlorophrin, (a pinosylvin analogue), which had hitherto been identified in Iroko tree by Grundon and King [8]
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A thesis submitted to the Department of Chemistry, Faculty of Science, University of Science and Technology, Kumasi in partial fulfillment of the requirements for the degree of Master of Science (Organic Chemistry),1994.
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