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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3565

Title: A ultra-violet/visible spectrophotometric method of assay of nifedipine
Authors: Martey, Jonathan Yaw
Issue Date: 16-Sep-1997
Series/Report no.: 2556;
Abstract: Three ultraviolet-visible spectrophotometric methods are described for the determination of nifedipine in its pure state and in encapsulated and tableted dosage forms. The drug was reduced and the resulting amino derivative was treated variously with reagents and determined spectrophotometricallv at 245nm and 435nm. The results obtained by these methods were compared with those obtained with the official USP method on the same sample batches. The methods were accurate and precise. The detection limit obtained for nifedipine with the proposed methods was in the region of 20 μg/ml. Some commercial brands of nifedipine available on the Ghanaian market were analysed by the proposed methods and found to contain levels of nifedipine within the USP specification range of 90- 110%.
Description: A thesis submitted to the Board of Postgraduate Studies, Kwame Nkrumah University of Science and Technology, Kumasi, in partial fulfilment of the requirements for the award of the Degree of Master of Science, 1997
URI: http://hdl.handle.net/123456789/3565
Appears in Collections:College of Science

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