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|Title: ||Prophylactic antibiotic during caesarean sections at Komfo Anokye Teaching Hospital, Kumasi|
|Authors: ||Opoku, Baafuor K.|
|Keywords: ||Caesarean section|
|Issue Date: ||2007|
|Publisher: ||Ghana Medical Journal|
|Citation: ||Ghana Medical Journal, Volume 41, Number 2, 2007|
|Abstract: ||Objectives: To compare the efficacy of coamoxiclav
(amoxicillin + clavulanic acid) and the
triple therapy of ampicillin + gentamycin + metronidazole
as prophylactic antibiotic during Caesarean
Design: A randomized controlled trial.
Setting: The study was conducted between March
and December 2002 at Komfo Anokye Teaching
Participants: Patients undergoing caesarean section
were recruited into the study and given either
drug as prophylaxis. Excluded were patients who
had established infections prior to the operation,
had had any antibiotic in the preceding 24 hours
and those allergic to any of the trial drugs.
Interventions: A total of 320 patients were recruited
and randomized on a one-to-one basis into
two groups, 160 receiving co-amoxiclav whilst
the other 160 received the triple therapy. In either
case the drug was given as a single intravenous
dose after cord clamping and repeated 12 hours
later. No other antibiotic was given except in cases
where frank infection was apparent postoperatively.
Outcome measures: Included abdominal wound
infection, cough, dysuria, fever, uterine tenderness
and offensive lochia after surgery.
Results: Abdominal wound infection was found in
rates lower than in a previous study: 3.7% in the
co-amoxiclav group and 13.1% in the triple therapy
group as against 15.1% in the previous study.
Co-amoxiclav was statistically found superior to
the Triple Therapy in preventing abdominal wound
infection and uterine tenderness. There was however,
no statistical difference between the two
groups as far as the prevention of cough, dysuria
and fever were concerned.
Conclusion: Co-amoxiclav was found to be a better
|Description: ||Article published in GHANA MEDICAL JOURNAL, Volume 41, Number 2, June 2007|
|Appears in Collections:||College of Health Sciences|
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