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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5099

Title: Hispidulin and other Constituents of Scoparia Dulcis Linn
Authors: Osei-Safo, D.
Chama, M. A.
Addae-Mensah, I.
Waibel, R.
Keywords: Scoparia dulcis
flavones
hispidulin,
β-sitosterol-β-D-glucoside,
anti-HIV
Issue Date: 2009
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 29, No. 2, Aug., 2009, pp 7-15
Abstract: Phytochemical investigation of the ethanol extract of the whole plant of Scoparia dulcis, has resulted in the isolation of 4, 5, 7-trihydroxy-6-methoxyflavone, commonly called hispidulin and a steroidal glycoside, β-sitosterol-β-D-glucoside. This is the first isolation of the two compounds from S. dulcis. Also isolated and characterized were the previously reported 6-methoxybenzoxazolinone, friedelan-3-one and scopadulcic acid B. Structural elucidation was done on the basis of spectroscopic data interpretations (IR, UV, NMR and EIMS). Using the Tetrazolium-based colorimetric selective assay, hispidulin was found to be inactive against HIV-1/IIIB in MT-4 cells whereas the same test on the aqueous extract of the plant was positive.
Description: Article published in the Journal of Science and Technology, Vol. 29, No. 2, Aug., 2009, pp 7-15
URI: http://hdl.handle.net/123456789/5099
Appears in Collections:Journal of Science and Technology 2000-

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