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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5144

Title: Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana
Authors: Dickson, Rita A.
Houghton, Peter J.
Hylands, Peter J.
Issue Date: 5-Apr-2007
Publisher: Phytochemistry
Citation: Phytochemistry 68 (2007) 1436-1441
Abstract: Bioactivity-guided fractionation of the light petroleum extract of Caesalpinia benthamiana Mezoneuron benthamianum) root bark has led to the isolation of two cassane diterpenoids, designated as benthaminin I and 2. A third compound, a deoxy form of caesaldekarin C (also referred to as methyl vouacapenate) which has previously been isolated from Caesalpinia major, C. bonducella, Vouacapoua americana and V. macropetala, was also isolated, together with p-sitosterol and stigmastenone. The antibacterial and antioxidant activities of these cassane diterpenoids have been assessed using the microdilution assay method and DPPH spectrophotometric and TBA lipid peroxidation assays. Benthaminin I was the more active antibacterial compound with MIC values of 47.8 flM for both Staphylococcus aureus and Micrococcusflavus. Benthaminin 2 was the more active antioxidant compound and showed ICso values of 42.7 uM and 74.2 uM for the DPPH and TBA assays, respectively. Deoxycaesaldckarin C possessed both antibacterial and antioxidant activities. The presence of methyl ester and methyl functional groups as well as an unsaturated furan ring appears to confer antibacterial activity. On the other hand, the relatively stronger antioxidant activity of benthaminin 2 may be associated with the presence of an exocyclic methylene function.
Description: This article was published by Phytochemistry 68, (2007), 1436-1441
URI: http://hdl.handle.net/123456789/5144
Appears in Collections:College of Health Sciences

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