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|Title: ||In Vitro Evaluation of Effects of Two Ghanaian Plants Relevant to Wound Healing|
|Authors: ||Mensah, Abraham Y.|
Houghton, Peter J.
Dickson, Rita A.
Fleischer, Theophilus C.
|Keywords: ||Commelina diffuse|
|Issue Date: ||14-Aug-2006|
|Publisher: ||Phytotherapy Research|
|Citation: ||Phytotherapy Research, 20, 941-944 (2006)|
|Abstract: ||Commelina diffusa and Spathodea campanu/ata are used as wound-healing agents in Ashanti traditional medicine in Ghana. The methanol extracts of Commelina diffusa herb and Spathodea campanulata bark
showed some level of antimicrobial activity with C. diffusa exhibiting selective antifungal activity against
Trichophyton species. The extracts reduced the peroxidation of bovine brain extract with an IC50 value
of 1.39 ug/mL and 0.24 ug/mL, respectively. In addition the extracts also exhibited significant antioxidant
activity by protecting MRC-5 cells from hydrogen peroxide induced oxidant injury at concentrations between
1 ug/mL and 10 ug/mL. The extracts showed no inhibition of NF-Idl at 100 ug/mL. The antioxidant activities
and antimicrobial activities suggest that the use of the plants in wound healing may be based 011 antioxidant
and antiseptic effects of its constituents.|
|Description: ||This article was published by Phytotherapy Research, 20, 941-944 (2006)|
|Appears in Collections:||College of Health Sciences|
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