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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5171

Title: The Modulation of Haemolytic Activity of Non-Ionic Surfactants by Oil-In-Water Microemulsions as Vehicles for Parenteral Drug Delivery
Authors: Bayor, M.T.
Lawrence, M.J.
Keywords: Oil-in-water (o/w) microemulsions
micellar solutions
non-ionic surfactants
haemolytic activity
drug delivery
parenteral administration
Issue Date: Aug-2007
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 27 No. 2, 2007 pp 41-50
Abstract: Microemulsions are thermodynamically stable, clear, transparent fluid dispersions of oil, water, and surfactant, but may include a cosurfactant typically a short chain alcohol. The unique properties of microemulsions make them suitable candidates as vehicles for improving parenteral drug delivery. In the present study, we report of our investigations into the ability of some commercial non-ionic surfactants to produce o/w microemulsions with different oils and water or phosphate buffered saline (PBS), their physicochemical properties and modulation of liaemolytic activity on human erythrocytes. The compositions over which clear o/w microemulsion systems formed and their areas of existence were dependent on the structure of the non-ionic surfactant and the oil incorporated. The clear o/w microemulsion systems remained clear and stable even on dilution with water or PBS. The liaemolytic activities of the micellar solutions of the non-ionic surfactants were dependent on the nature and concentration of the surfactant. Generally, the dear o/w microemulsion systems were greatly less liaemolytic than their corresponding micellar solutions at equivalent concentrations of surfactant. This indicated a high modulation of the liaemolytic activity of the surfactants by the microemulsion formulations. The modulation of liaemolytic activity was greatest with microemulsions formulated with the highest possible oil/surfactant ratios. The use of relatively longer triglycerides (oils) greatly enhanced the modulation activity of the resultant microemulsions. Our findings signified a high level of safety associated with the o/w microemulsions and lent a good support and credence to the high potential of microemulsions as suitable and safe vehicles for parenteral drug administration.
Description: Article published in the Journal of Science and Technology, Vol. 27 No. 2, 2007 pp 41-50
URI: http://hdl.handle.net/123456789/5171
Appears in Collections:Journal of Science and Technology 2000-

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