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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5178

Title: Morphological and Behavioural Features of Bewo Cells Grown on Matrigel Offers: A Model for Human Cytotro- Phoblast Cells during Early Implantation
Authors: Abaidoo, C.S.
Warren, M.A.
Keywords: BeWo cells
Trophoblast
Morphology
Matrigel
Implantation
Issue Date: Apr-2008
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 28 No. 1, 2008 pp 14-16
Abstract: In order to observe the morphological changes that occur in cell-cell and cell-malrix interactions among trophoblast cells and other neighbouring cells during human implantation, BeWo cells were cultured in a 3-dimensional artificial extracellular matrix (Matrigel) using a double-chamber system. These cultures were then processed for light and electron microscopical examination. Results obtained show that the morphology and behavioural pattern of BeWo cells grown on Matrigel is similar to that reported for in vitro normal human cytotrophoblast cells on extracellular matrix (ECM). These results suggest that culture of BeWo cells on extracellular matrices may be useful for the study of some of the early embryonic events leading to human implantation, especially during the period when trophoblastic cells interact with and erode the uterine epithelium and ECM.
Description: Article published in the Journal of Science and Technology, Vol. 28 No. 1, 2008 pp 14-16
URI: http://hdl.handle.net/123456789/5178
Appears in Collections:Journal of Science and Technology 2000-

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