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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5187

Title: Detection of Weak D (Du) Phenotype among Rh-D Negative Males And Females in Kumasi, Ghana
Authors: Opoku-Okrah, C.
Amidu, N.
Amoah-Sakyi, S.
Keywords: Rhesus D
weak Rh D
, indirect antiglobulin test
Issue Date: Dec-2008
Publisher: Journal of Science and Technology
Citation: Journal of Science and Technology, Vol. 28 No. 3, 2008 pp 34-40
Abstract: Weak Rh D phenotypes are very frequent in Africans. They are capable of causing alloimmunization in Rh D-negative individuals. Some weak Ds may elude routine typing using direct agglutination techniques. This study aimed at determining the prevalence of weak D phenotype among Rh; negatives, using indirect antiglobulin technique. A total of 400 donors between the ages of 16 and 35 years who were grouped by the blood bank were randomly sampled over a period of 2 months. Three hundred and sixty nine (92.25%) were typed as Rh D-positive and 31 (7.75%) RhD-negative. Two (6.45%) of the Rh D-negative donors were weak D positive while 29 (93.55%) were weak negative. Among the males, 25 (9.43%) were Rh D-negative and 240 (90.57%) RhD-positive. Two (8%) of the 25 males were weak D positive. Among the females, 6 (4.44%) were Rh D-negative and 129 (95.56%) RhD- positive. This implies that, there are people in Kumasi with weak D phenotype which cannot be detected by the direct monoclonal anti-D agglutination. Consequently, indirect antiglobulin test may be indicated for such individuals typed Rh D-negative. This study has shown the need for a comprehensive policy on appropriate testing of donors and newborns, and management of Rh D-negative mothers in the Region. This should include weak D testing of all Rh D-negative blood donors before transfusion in Rh D-negative patient.
Description: Article published in the Journal of Science and Technology, Vol. 28 No. 3, 2008 pp 34-40
URI: http://hdl.handle.net/123456789/5187
Appears in Collections:Journal of Science and Technology 2000-

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