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Title: | Lowered Serum Triglyceride Levels among Chronic Hepatitis B-Infected Patients in Ghana |
Authors: | Kwarteng, J. K. Owusu, L. Afihene, M. Mica, E. Opare-Sem, O. Arthur, F.K.N. |
Keywords: | chronic hepatitis B lipid metabolism triglyceride chronic symptomatic |
Issue Date: | Dec-2012 |
Publisher: | Journal of Science and Technology |
Citation: | Journal of Science and Technology, Vol. 32, No. 3, 2012, pp 1-10 |
Abstract: | Dyslipidemia is a common finding in most studies of liver diseases. Little is however known
about the effect of the two pathological stages of chronic hepatitis B (CHB) infection – chronicsymptomatic
and asymptomatic – on the distribution of serum lipids in CHB infection. We conducted
a study on CHB-infected patients attending specialist care at the Gastro-Intestinal (GI)
Clinic at the Komfo Anokye Teaching Hospital (KATH) during a 7-month period. 64 participants
were randomly sampled over the period. On the basis of serological and liver enzyme assays,
participants were categorised as chronic asymptomatic, chronic symptomatic and healthy
individuals. The relationship between the hosts pathological stage of infection were evaluated
with the indices of lipid metabolism – LDL, HDL, triglyceride, and total serum cholesterol using
ANOVA. The 64 volunteers recruited in the study were found to consist of 18 patients (28.1%)
who were chronic symptomatic, 35 patients (54.7%) who were chronic asymptomatic hepatitis B,
and 11 (17.2%) were healthy subjects. Significant overall male dominance was observed among
all categories of population enrolled (p=0.0063). Serum triglyceride levels decreased more
among the CHB-infected population compared to the healthy individuals (p=0.0010) with value
lowest among the chronic symptomatic population. Basal serum cholesterol, HDL, and LDL
were unaffected by the disease. This work reveals that serum triglyceride is significantly lowered
in CHB infection and that the extent of this decrease in host is independent of the pathological
stage of the infection. |
Description: | Article published in the Journal of Science and Technology, Vol. 32, No. 3, 2012, pp 1-10 |
URI: | http://hdl.handle.net/123456789/5667 |
Appears in Collections: | Journal of Science and Technology 2000-
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