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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/5713

Title: Iron Deficiency in Relation to Cognitive Function Among Ghanaian Children of School Going Age in the Bosomtwi Atwima Kwanwoma District of Ghana.
Authors: Opoku, Samuel Kwame
Issue Date: 12-Oct-2012
Abstract: Iron deficiency has been implicated in cognitive function decline. This study looked at the relationship between iron status and cognitive function among children of school-going age to assess the effect of iron therapy on cognition and growth. In all, two hundred and eighty eight (288) school children between the ages of 6-11 years took part in the study. The participants for the study were recruited from public schools in the Bosomtwe Atwima Kwanwoma district. Venous blood samples were taken for all the relevant haematological parameters and biochemical assays (ferritin and transferrin receptors). Anthropometric assessment was done for weight and height. Cognitive function assessment to determine IQ was also performed using the Test of Non-verbal Intelligence (TONI-3) by trained testers. The data obtained from this study was analysed using the t test, fisher’s exact test, one way analysis of variance and Pearson’s product moment correlation. Haematological and anthropometric parameters improved to a significant level after supplementation. There was a significant negative correlation (p<0.05) between Hb and IQ score highlighting the effects of anaemia on cognitive function. The effect of wasting on cognitive function was clearly shown by the negative correlation (p < 0.001) between weight for height z-score and IQ score. From the study, treatment generally had a significant positive effect on weight, height, BMI and PI. Among the supplementation groups (subjects and controls) significant differences after supplementation were in haemoglobin, prevalence of anaemia, ferritin and MCHC. Treatment had a generally significant positive effect on weight, ponderal index and IQ of the subject group. The age of the studied population generally had a significant negative correlation with IQ. The situation after supplementation was different with a significant difference only in the mean Hb levels, showing the positive effects of supplementation on the iii haematological parameters especially in the anaemic group. In the non-anaemic group treatment had a generally positive effect on IQ, weight, height, ponderal index and body mass index. In the anaemic group however treatment had no positive effect on IQ score. Between the iron deficiency and iron replete groups, weight and height had a positive correlation with IQ in this population highlighting the importance of good nutrition in cognitive development. A significant difference was observed between the cognitive function score (p = 0.0431) of the iron deficient and IR groups resulting from an increase in the IQ of the iron deficient group after supplementation. The findings of this study clearly indicate that improving iron status is associated with a concomitant improvement in cognitive function score and growth rate. We propose from the study that there exist a strong correlation between iron status and cognitive function and by ensuring good nutrition intake among children at an early age iron deficiency could be averted and thus help in the progressive but gradual and significant improvement in cognitive function
Description: A Thesis Submitted to Kwame Nkrumah University of Science and Technology in partial fulfillment of the requirements for the Degree Of Doctor of Philosophy, October-2012
URI: http://hdl.handle.net/123456789/5713
Appears in Collections:College of Health Sciences

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