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|Title: ||Insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa.|
|Authors: ||Vandelannoote, K|
Phillips, Richard O.
de Jong, BC
|Issue Date: ||Feb-2014|
|Publisher: ||Applied and Enviromental Microbiology|
|Citation: ||Appl Environ Microbiol. 2014 Feb;80(3):1197-209|
|Abstract: ||Buruli ulcer is an indolent, slowly progressing necrotizing disease of the skin caused by infection with Mycobacterium ulcerans. In the present study, we applied a redesigned technique to a vast panel of M. ulcerans disease isolates and clinical samples originating from multiple African disease foci in order to (i) gain fundamental insights into the population structure and evolutionary history of the pathogen and (ii) disentangle the phylogeographic relationships within the genetically conserved cluster of African M. ulcerans. Our analyses identified 23 different African insertion sequence element single nucleotide polymorphism (ISE-SNP) types that dominate in different areas where Buruli ulcer is endemic. These ISE-SNP types appear......|
|Description: ||Article published in Appl Environ Microbiol. 2014 Feb;80(3):1197-209. doi: 10.1128/AEM.02774-13. Epub 2013 Dec 2.|
|Appears in Collections:||Publications|
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