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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7105

Title: The spike protein of the emerging metacoronavirus EMC uses a novel coronavirus receptor for entry, can be activated by TMPRSS2, and Is targeted by neutralizing antibodies
Authors: Gierer, Stefanie
Bertram, Stephanie
Kaup, Franziska
Wrensch, Florian
Heurich, Adeline
Krämer-Kühl, Annika
Welsch, Kathrin
Winkler, Michael
Meyer, Benjamin
Drosten, Christian
Dittmer, Ulf
von Hahn, Thomas
Simmons, Graham
Hofmann, Heike
Pöhlmann, Stefan
Issue Date: May-2013
Publisher: Journal of Virology
Citation: Virol. May 2013; 87(10): 5502–5511.
Abstract: The novel human coronavirus EMC (hCoV-EMC), which recently emerged in Saudi Arabia, is highly pathogenic and could pose a significant threat to public health. The elucidation of hCoV-EMC interactions with host cells is critical to our understanding of the pathogenesis of this virus and to the identification of targets for antiviral intervention. Here we investigated the viral and cellular determinants governing hCoV-EMC entry into host cells. We found that the spike protein of hCoV-EMC (EMC-S) is incorporated into lentiviral particles and mediates transduction of human cell lines derived from different organs, including the......
Description: Virol. May 2013; 87(10): 5502–5511. doi: 10.1128/JVI.00128-13
URI: http://hdl.handle.net/123456789/7105
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