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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7113

Title: Mechanical and tablet coating properties of cashew tree (anacardium occidentale l) gum-based films
Authors: Ofori-Kwakye, Kwabena
Amekyeh, Hilda
El-Duah, Mariam
Kipo, Samuel Lugrie
Keywords: Anacardium occidentale
Cashew gum
film coating
mechanical properties of films
non-functional coating
Issue Date: 2012
Publisher: Asian Journal of Pharmaceutical and Clinical Research
Citation: Asian Journal of Pharmaceutical and Clinical Research Vol 5, Suppl 4, 2012 pp. 62-68
Abstract: The mechanical and coating properties of cashew gum-based films, using paracetamol as a model drug, was investigated. Cashew gum was acidic and the acidity did not markedly change with concentration and storage time. However, gum viscosity increased significantly with concentration and storage time. Swelling index of the gum was ~ 3.3 and was largely unaffected by pH of media used. Free films of cashew gum, cashew gum/hydroxypropyl methylcellulose (HPMC), and cashew gum/ carboxymethyl cellulose (CMC) were prepared by solvent casting using glycerol as a plasticizer and the folding endurance, tensile strength, percentage elongation and Young’s modulus of the films determined. Cashew gum films were smooth, uniform and transparent while cashew gum/HPMC and cashew gum/CMC films lacked uniformity and surface smoothness, respectively. Addition of a plasticizer to the gum imparted flexibility to the films. Increase in cashew gum and plasticizer concentration increased the folding endurance and percentage elongation of the films. Tensile strength increased with increase in gum concentration but decreased with increase in plasticizer concentration. Young’s modulus decreased when cashew gum and plasticizer concentrations were increased. Film coating of 7.5 % w/v cashew gum formulation to paracetamol tablet cores enhanced the mechanical strength of the tablets. However, film coating of the tablet cores did not markedly affect disintegration and drug release properties of the tablets compared to the uncoated tablets. Also, no significant difference in drug release was observed in 0.1 M HCl (pH 1.5) and phosphate buffer pH 6.8 used. Cashew gum when applied at 7.5 % w/v could be useful as non-functional film coatings for conventional solid dosage forms.
Description: Asian Journal of Pharmaceutical and Clinical Research Vol 5, Suppl 4, 2012 pp. 62-68
URI: http://hdl.handle.net/123456789/7113
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