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http://hdl.handle.net/123456789/7118
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Title: | Effect of xylopic acid on sex hormones and spermatogenesis in male rats. |
Authors: | Woode, Eric Alhassan, Abass Abaidoo, Chrissie Stansie |
Keywords: | Spermatogenesis anti-androgen xylopic acid Sex hormones |
Issue Date: | 2012 |
Publisher: | Al Ameen J Med Sci. |
Citation: | Al Ameen J Med Sci; Volume 5, No.3, 2012 |
Abstract: | Fruit extracts of Xylopia aethiopica has been shown to possess
antimicrobial, cardiovascular, diuretic, cytotoxic, anti-proliferative, and spermatogenic
activity. These activities are attributed to the kaurane derivatives of which Xylopic acid (XA)
is a major component. It is worth stating that no study has examined the effects of XA on
spermatogenesis and reproductive function. Objective: The present study was thus intended to
evaluate the effect of XA on serum sex hormone levels and spermatogenesis in male rats.
Methods: Xylopic acid was administered orally to male Sprague-Dawley rats at the doses of
10, 30 and 100 mg kg-1 for 28 days. Blood was collected into eppendorf tubes from the
saphenous veins of animals on day 7 of the treatment and on day 28 after which the rats were
euthanized to removed testes and other organs. Results and Discussion: Xylopic acid did not
cause any changes in body weight, but significantly decrease testicular and epididymal weight
(P < 0.01). Sperm motility, viability, and epididymal sperm counts of rats administered with
XA for 28 days were significantly reduced (P < 0.01). Serum testosterone levels were
significantly reduced (P < 0.01). There were various degrees of damage to the seminiferous
tubules. Reversal of these changes, however, occurred after two weeks of recovery.
Conclusion: Xylopic acid thus possesses anti-androgenic and spermatotoxic properties the
mechanism of which may involve direct effect on germ cells and other cells in the testes. |
Description: | Article published in Al Ameen J Med Sci; Volume 5, No.3, 2012 |
URI: | http://hdl.handle.net/123456789/7118 |
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