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|Title: ||Effect of xylopic acid on sex hormones and spermatogenesis in male rats.|
|Authors: ||Woode, Eric|
Abaidoo, Chrissie S.
|Issue Date: ||2012|
|Publisher: ||Al Ameen J Med Sci.|
|Citation: ||Al Ameen J Med Sci; Volume 5, No.3, 2012|
|Abstract: ||Fruit extracts of Xylopia aethiopica has been shown to possess
antimicrobial, cardiovascular, diuretic, cytotoxic, anti-proliferative, and spermatogenic
activity. These activities are attributed to the kaurane derivatives of which Xylopic acid (XA)
is a major component. It is worth stating that no study has examined the effects of XA on
spermatogenesis and reproductive function. Objective: The present study was thus intended to
evaluate the effect of XA on serum sex hormone levels and spermatogenesis in male rats.
Methods: Xylopic acid was administered orally to male Sprague-Dawley rats at the doses of
10, 30 and 100 mg kg-1 for 28 days. Blood was collected into eppendorf tubes from the
saphenous veins of animals on day 7 of the treatment and on day 28 after which the rats were
euthanized to removed testes and other organs. Results and Discussion: Xylopic acid did not
cause any changes in body weight, but significantly decrease testicular and epididymal weight
(P < 0.01). Sperm motility, viability, and epididymal sperm counts of rats administered with
XA for 28 days were significantly reduced (P < 0.01). Serum testosterone levels were
significantly reduced (P < 0.01). There were various degrees of damage to the seminiferous
tubules. Reversal of these changes, however, occurred after two weeks of recovery.
Conclusion: Xylopic acid thus possesses anti-androgenic and spermatotoxic properties the
mechanism of which may involve direct effect on germ cells and other cells in the testes.|
|Description: ||Article published in Al Ameen J Med Sci; Volume 5, No.3, 2012|
|Appears in Collections:||Publications|
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