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Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/7118

Title: Effect of xylopic acid on sex hormones and spermatogenesis in male rats.
Authors: Woode, Eric
Alhassan, Abass
Abaidoo, Chrissie S.
Keywords: Spermatogenesis
anti-androgen
xylopic acid
Sex hormones
Issue Date: 2012
Publisher: Al Ameen J Med Sci.
Citation: Al Ameen J Med Sci; Volume 5, No.3, 2012
Abstract: Fruit extracts of Xylopia aethiopica has been shown to possess antimicrobial, cardiovascular, diuretic, cytotoxic, anti-proliferative, and spermatogenic activity. These activities are attributed to the kaurane derivatives of which Xylopic acid (XA) is a major component. It is worth stating that no study has examined the effects of XA on spermatogenesis and reproductive function. Objective: The present study was thus intended to evaluate the effect of XA on serum sex hormone levels and spermatogenesis in male rats. Methods: Xylopic acid was administered orally to male Sprague-Dawley rats at the doses of 10, 30 and 100 mg kg-1 for 28 days. Blood was collected into eppendorf tubes from the saphenous veins of animals on day 7 of the treatment and on day 28 after which the rats were euthanized to removed testes and other organs. Results and Discussion: Xylopic acid did not cause any changes in body weight, but significantly decrease testicular and epididymal weight (P < 0.01). Sperm motility, viability, and epididymal sperm counts of rats administered with XA for 28 days were significantly reduced (P < 0.01). Serum testosterone levels were significantly reduced (P < 0.01). There were various degrees of damage to the seminiferous tubules. Reversal of these changes, however, occurred after two weeks of recovery. Conclusion: Xylopic acid thus possesses anti-androgenic and spermatotoxic properties the mechanism of which may involve direct effect on germ cells and other cells in the testes.
Description: Article published in Al Ameen J Med Sci; Volume 5, No.3, 2012
URI: http://hdl.handle.net/123456789/7118
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